Skip to main content

MW 206.28 Da, Purity >99%. Non-selective COX inhibitor (IC50 values are 2.9 and 1.1 μM for COX1 and COX2, respectively). Non-steroidal anti-inflammatory drug (NSAID). Rapidly crosses the blood-brain barrier.

Be the first to review this product! Submit a review

Images

Chemical Structure - (S)-(+)-Ibuprofen, Non-selective COX inhibitor (AB141015), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - (S)-(+)-Ibuprofen, Non-selective COX inhibitor (AB141015), expandable thumbnail

Publications

Key facts

CAS number

51146-56-6

Purity

> 99%

Form

Solid

Molecular weight

206.28 Da

Molecular formula

C13H18O2

PubChem identifier

39912

Nature

Synthetic

Alternative names

Recommended products

MW 206.28 Da, Purity >99%. Non-selective COX inhibitor (IC50 values are 2.9 and 1.1 μM for COX1 and COX2, respectively). Non-steroidal anti-inflammatory drug (NSAID). Rapidly crosses the blood-brain barrier.

Key facts

Purity

> 99%

PubChem identifier

39912

Solubility

Soluble in DMSO to 100 mM. Soluble in ethanol to 100 mM.

Biochemical name

Dexibuprofen

Biological description

Non-selective COX inhibitor (IC50 values are 2.9 and 1.1 μM for COX1 and COX2, respectively). Non-steroidal anti-inflammatory drug (NSAID). Rapidly crosses the blood-brain barrier.

Canonical SMILES

CC(C)CC1=CC=C(C=C1)C(C)C(=O)O

Isomeric SMILES

C[C@@H](C1=CC=C(C=C1)CC(C)C)C(=O)O

InChI

InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1

InChIKey

HEFNNWSXXWATRW-JTQLQIEISA-N

IUPAC name

(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cyclooxygenase (COX) enzymes including COX-1 and COX-2 also known as prostaglandin-endoperoxide synthase 1 and 2 are involved in the conversion of arachidonic acid to prostaglandins. COX-1 typically weighs about 70 kDa while COX-2 is around 72 kDa. COX-1 is constitutively expressed in most tissues providing homeostatic functions whereas COX-2 expression is inducible and often upregulated in specific tissues during inflammation or other pathophysiological conditions. COX enzymes are important targets for non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen which acts as a COX inhibitor; these drugs help to reduce inflammation and pain.

Biological function summary

The cyclooxygenase enzymes play essential roles in mediating the inflammatory response regulating vascular homeostasis and protecting the gastric mucosa. COX-2 in particular is usually expressed during inflammatory processes and is part of the cellular response to cytokines and growth factors. It is involved in the synthesis of pro-inflammatory prostaglandins and when upregulated can significantly increase inflammation at the injury or infection site. COX inhibitors including ibuprofen and others target these enzymes to modulate these biological functions effectively.

Pathways

The COX enzymes are key components of the prostaglandin synthesis pathway. They catalyze the rate-limiting step of this pathway helping convert arachidonic acid to prostaglandin H2 a precursor of various prostaglandins and thromboxanes. COX-2's activity in the inflammation pathway is linked with the nuclear factor kappa B (NF-κB) pathway which regulates the immune response. AKR1C3 another enzyme related to the production of prostaglandins interacts in similar pathways highlighting the interconnected nature of these biological processes.

Associated diseases and disorders

COX-2 is strongly associated with inflammation-related conditions such as arthritis and cancer. For instance overexpression of COX-2 is found in several cancers and contributes to tumor growth and metastasis. COX-1 while less associated with inflammation plays a role in maintaining gastrointestinal integrity. NSAIDs like ibuprofen which target COX enzymes help manage pain and inflammation in conditions like arthritis but can have side effects such as gastrointestinal irritation due to COX-1 inhibition. CXCR2 and TDP-43 are other proteins that may interact with the inflammatory pathways COX-2 is involved in potentially influencing both disease progression and therapy outcomes.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Chemical Structure - (S)-(+)-Ibuprofen, Non-selective COX inhibitor (ab141015), expandable thumbnail

    Chemical Structure - (S)-(+)-Ibuprofen, Non-selective COX inhibitor (ab141015)

    2D chemical structure image of ab141015, (S)-(+)-Ibuprofen, Non-selective COX inhibitor

  • Immunocytochemistry/ Immunofluorescence - (S)-(+)-Ibuprofen, Non-selective COX inhibitor (ab141015), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - (S)-(+)-Ibuprofen, Non-selective COX inhibitor (ab141015)

    Anti-Hsc70 antibody ab125307 staining HSC70 in HeLa cells treated with (S)-(+)-ibuprofen (ab141015), by ICC/IF. Increase of HSC70 nuclear expression correlates with increased concentration of (S)-(+)-ibuprofen, as described in literature.
    The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141015 ((S)-(+)-ibuprofen) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-Hsc70 antibody ab125307 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com