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AB120059

(S)-MCPG, Group I / II mGlu antagonist

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(10 Publications)

Group I / II mGluR (metabotropic glutamate receptors) competitive antagonist with some activity reported at mGluR8. MW 209.2.

- Group 1 (mGluR1 and mGluR5 ) and Group 2 (mGluR2 and mGluR3)
- Active isomer of (R,S)-MCPG (ab120033)
- Available in different sizes to fit your experimental needs

View Alternative Names

AMPA-selective glutamate receptor 2, GLUR, GPRC1A, GPRC1B, GRM1-Alpha, GRM1_HUMAN, GRM2_HUMAN, GluR-2, GluR-B, Glutamate metabotropic receptor 2, Glutamate receptor homolog, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 2, MGLU1, MGLUR2, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2, OTTHUMP00000210984, OTTHUMP00000210986, SCAR13, Smp_128940, mGlu2, mGluR1

2 Images
Chemical Structure - (S)-MCPG, Group I / II mGlu antagonist (AB120059)
  • Chemical Structure

Lab

Chemical Structure - (S)-MCPG, Group I / II mGlu antagonist (AB120059)

2D chemical structure image of ab120059, (S)-MCPG, Group I / II mGlu antagonist

Immunocytochemistry/ Immunofluorescence - (S)-MCPG, Group I / II mGlu antagonist (AB120059)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - (S)-MCPG, Group I / II mGlu antagonist (AB120059)

ab17722 staining FMRP in SK-N-SH cells treated with (S)-MCPG (ab120059), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (S)-MCPG, as described in literature.
The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120059 ((S)-MCPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Key facts

CAS number

146669-29-6

Purity

>98%

Form

Solid

form

Molecular weight

209.2 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>1</sub><sub>1</sub>NO<sub>4</sub>

PubChem

446355

Nature

Synthetic

Solubility

Soluble in 1.1eq. NaOH to 100mM

Biochemical name

(S)-Mcpg

Biological description

Active isomer of (R,S)-MCPG (ab120033). Group I / II mGlu receptor antagonist with some activity reported at mGlu8.

Canonical smiles

CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N

Isomeric smiles

C[C@](C1=CC=C(C=C1)C(=O)O)(C(=O)O)N

InChi

InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1

InChiKey

DNCAZYRLRMTVSF-JTQLQIEISA-N

IUPAC Name

4-[(1S)-1-amino-1-carboxyethyl]benzoic acid

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Product details

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of 111:4303-8 PubMed24550458

2014

Mossy fiber-evoked subthreshold responses induce timing-dependent plasticity at hippocampal CA3 recurrent synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Federico Brandalise,Urs Gerber

Neuron 75:58-64 PubMed22794260

2012

Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah Threlfell,Tatjana Lalic,Nicola J Platt,Katie A Jennings,Karl Deisseroth,Stephanie J Cragg

PloS one 7:e36397 PubMed22570709

2012

Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.

Applications

Unspecified application

Species

Unspecified reactive species

Nicola J Platt,Suzana Gispert,Georg Auburger,Stephanie J Cragg

Experimental neurology 233:292-302 PubMed22056941

2011

A continuous high frequency stimulation of the subthalamic nucleus determines a suppression of excitatory synaptic transmission in nigral dopaminergic neurons recorded in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Ada Ledonne,Dalila Mango,Giorgio Bernardi,Nicola Berretta,Nicola Biagio Mercuri

Neuropsychopharmacology : official publication of 36:1811-22 PubMed21508928

2011

Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.

Applications

Unspecified application

Species

Unspecified reactive species

Henrike Hartung,Sarah Threlfell,Stephanie J Cragg

British journal of pharmacology 163:984-94 PubMed21366553

2011

Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2.

Applications

Unspecified application

Species

Unspecified reactive species

J Gan,S M Greenwood,S R Cobb,T J Bushell

Journal of neurophysiology 104:3413-23 PubMed20861429

2010

Long-term depression at parallel fiber to Golgi cell synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Quinten Robberechts,Mike Wijnants,Michele Giugliano,Erik De Schutter

The Journal of physiology 588:1499-514 PubMed20211977

2010

Simulated ischaemia induces Ca2+-independent glutamatergic vesicle release through actin filament depolymerization in area CA1 of the hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Adriana L Andrade,David J Rossi

The Journal of neuroscience : the official journal of the Society for Neuroscience 30:3398-408 PubMed20203199

2010

Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah Threlfell,Michael A Clements,Tansi Khodai,Ilse S Pienaar,Richard Exley,Jürgen Wess,Stephanie J Cragg

The Journal of neuroscience : the official journal of the Society for Neuroscience 30:1471-5 PubMed20107074

2010

Activation conditions for the induction of metabotropic glutamate receptor-dependent long-term depression in hippocampal CA1 pyramidal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Fan,Jeanne Ster,Urs Gerber
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