S-Trityl-cysteine, kinesin Eg5 inhibitor

Key facts

CAS number

25683-09-4

Purity

>98%

Form

Solid

form

Molecular weight

363.5 Da

Molecular formula

C₂₂H₂₁NO₂S

PubChem

256411

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Tritylcysteine

Biological description

Potent, cell-permeable kinesin Eg5 inhibitor (IC₅₀ = 140 nM). Blocks mitotic spindles and induces mitotic arrest in vitro. Antitumor and antimitotic agent. Active in vivo and in vitro.

Canonical smiles

C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCC(C(=O)O)N

InChi

InChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)

InChiKey

DLMYFMLKORXJPO-UHFFFAOYSA-N

IUPAC Name

2-amino-3-tritylsulfanylpropanoic acid