S3I-201 (DMSO solution), STAT3 inhibitor

Key facts

CAS number

501919-59-1

Purity

>97%

Form

Liquid

form

Molecular weight

365.4 Da

Molecular formula

C₁₆H₁₅NO₇S

PubChem

252682

Nature

Synthetic

Biochemical name

2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid

Biological description

Selective STAT3 inhibitor (IC₅₀ values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.

Canonical smiles

CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

InChi

InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)

InChiKey

HWNUSGNZBAISFM-UHFFFAOYSA-N

IUPAC Name

2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid