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MW 365.4 Da, Purity >97%. Selective STAT3 inhibitor (IC50 values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.

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Images

Chemical Structure - S3I-201, STAT3 inhibitor (AB141434), expandable thumbnail

Publications

Key facts

CAS number

501919-59-1

Purity

> 97%

Molecular weight

365.4 Da

Molecular formula

C16H15NO7S

PubChem identifier

252682

Nature

Synthetic

Recommended products

MW 365.4 Da, Purity >97%. Selective STAT3 inhibitor (IC50 values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.

Key facts

Purity

> 97%

PubChem identifier

252682

Biochemical name

2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid

Biological description

Selective STAT3 inhibitor (IC50 values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.

Canonical SMILES

CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

InChI

InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)

InChIKey

HWNUSGNZBAISFM-UHFFFAOYSA-N

IUPAC name

2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 1775 Stat3 Inhibitor I, S3I-201. 1775-25 is the same size as the 25 mg size of ab141434.

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1 product image

  • Chemical Structure - S3I-201, STAT3 inhibitor (ab141434), expandable thumbnail

    Chemical Structure - S3I-201, STAT3 inhibitor (ab141434)

    2D chemical structure image of ab141434, S3I-201, STAT3 inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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