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AB142235

Sal003, eIF2alpha phophatase inhibitor

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MW 463.21 g/mol, Purity >99%. Cell-permeable eIF2α phophatase inhibitor. Decreases cyclin D1 levels in vitro. Anticancer agent. Active in vitro and in vivo.
1 Images
Chemical Structure - Sal003, eIF2alpha phophatase inhibitor (AB142235)
  • Chemical Structure

Lab

Chemical Structure - Sal003, eIF2alpha phophatase inhibitor (AB142235)

2D chemical structure image of ab142235, Sal003, eIF2alpha phophatase inhibitor

Key facts

CAS number

1164470-53-4

Purity

>99%

Form

Solid

form

Molecular weight

463.21 g/mol

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>5</sub>Cl<sub>4</sub>N<sub>3</sub>OS

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Cell-permeable eIF2α phophatase inhibitor. Decreases cyclin D1 levels in vitro. Anticancer agent. Active in vitro and in vivo.

Isomeric smiles

CLC2CCC(NC(=S)NC(NC(=O)/C=C/C1CCCCC1)C(CL)(CL)CL)CC2

InChi

InChI=1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+

InChiKey

TVNBASWNLOIQML-IZZDOVSWSA-N

IUPAC Name

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Complementary Products

Primary Antibodies

AB169528

Anti-eIF2A antibody [EPR11042]

RabMAb|Recombinant|KO Validated

Western blot - Anti-eIF2A antibody [EPR11042] (AB169528)

  • 5
  • 5
Primary Antibodies

AB32157

Anti-EIF2S1 (phospho S51) antibody [E90]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EIF2S1 (phospho S51) antibody [E90] (AB32157)

  • 4
  • 27
Primary Antibodies

AB48187

Anti-IRE1 (phospho S724) antibody

Western blot - Anti-IRE1 (phospho S724) antibody (AB48187)

  • 4
  • 19
Primary Antibodies

AB192591

Anti-PERK (phospho T982) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PERK (phospho T982) antibody (AB192591)

  • 4
  • 19

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