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MW 231.23 Da, Purity >94%. Primary amine-reactive protein modification thiolating reagent. Adds protected sulfhydryls to targeted proteins. Induces stable recombinant TNF-α trimer formation by formation of disulfide bridges between reactive thiol groups on adjacent TNF-α molecules, which show increased therapeutic efficacy in vivo. .

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Images

Chemical Structure - SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent (AB145622), expandable thumbnail

Key facts

CAS number
76931-93-6
Purity
> 94%
Form
Solid
Molecular weight
231.23 Da
Molecular formula
C8H9NO5S
PubChem identifier
127532
Nature
Synthetic

Target data

Recommended products

MW 231.23 Da, Purity >94%. Primary amine-reactive protein modification thiolating reagent. Adds protected sulfhydryls to targeted proteins. Induces stable recombinant TNF-α trimer formation by formation of disulfide bridges between reactive thiol groups on adjacent TNF-α molecules, which show increased therapeutic efficacy in vivo. .

Key facts

Purity
> 94%
PubChem identifier
127532
Solubility

Soluble in DMSO to 4 mM.

Biochemical name
2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate
Biological description

Primary amine-reactive protein modification thiolating reagent. Adds protected sulfhydryls to targeted proteins. Induces stable recombinant TNF-α trimer formation by formation of disulfide bridges between reactive thiol groups on adjacent TNF-α molecules, which show increased therapeutic efficacy in vivo.

Canonical SMILES
CC(=O)SCC(=O)ON1C(=O)CCC1=O
InChI
InChI=1S/C8H9NO5S/c1-5(10)15-4-8(13)14-9-6(11)2-3-7(9)12/h2-4H2,1H3
InChIKey
FLCQLSRLQIPNLM-UHFFFAOYSA-N
IUPAC name
(2,5-dioxopyrrolidin-1-yl) 2-acetylsulfanylacetate

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2363 SATA. 2363-250 is the same size as the 250 mg size of ab145622.

Product promise

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1 product image

  • Chemical Structure - SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent (ab145622), expandable thumbnail

    Chemical Structure - SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent (ab145622)

    2D chemical structure image of ab145622, SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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