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AB145622

SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent

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MW 231.23 Da, Purity >94%. Primary amine-reactive protein modification thiolating reagent. Adds protected sulfhydryls to targeted proteins. Induces stable recombinant TNF-α trimer formation by formation of disulfide bridges between reactive thiol groups on adjacent TNF-α molecules, which show increased therapeutic efficacy in vivo. .
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Chemical Structure - SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent (AB145622)
  • Chemical Structure

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Chemical Structure - SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent (AB145622)

2D chemical structure image of ab145622, SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent

Key facts

CAS number

76931-93-6

Purity

>94%

Form

Solid

form

Molecular weight

231.23 Da

Molecular formula

C<sub>8</sub>H<sub>9</sub>NO<sub>5</sub>S

PubChem

127532

Nature

Synthetic

Solubility

Soluble in DMSO to 4 mM

Biochemical name

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

Biological description

Primary amine-reactive protein modification thiolating reagent. Adds protected sulfhydryls to targeted proteins. Induces stable recombinant TNF-α trimer formation by formation of disulfide bridges between reactive thiol groups on adjacent TNF-α molecules, which show increased therapeutic efficacy in vivo.

Canonical smiles

CC(=O)SCC(=O)ON1C(=O)CCC1=O

InChi

InChI=1S/C8H9NO5S/c1-5(10)15-4-8(13)14-9-6(11)2-3-7(9)12/h2-4H2,1H3

InChiKey

FLCQLSRLQIPNLM-UHFFFAOYSA-N

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 2-acetylsulfanylacetate

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2363 SATA. 2363-250 is the same size as the 250 mg size of ab145622.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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