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AB120638

SB 202190, cell-permeable p38 MAPK inhibitor

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(10 Publications)

MW 331.3 Da, Purity >99%. Highly selective, potent and cell-permeable p38 MAPK inhibitor (IC50 values are 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2, respectively). Selective over a wide range of other kinases. Apoptosis and autophagy inducer. 3D Growth matrix component and additive for long term growth; also component of gastric organoid culture media.
2 Images
Immunocytochemistry/ Immunofluorescence - SB 202190, cell-permeable p38 MAPK inhibitor (AB120638)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - SB 202190, cell-permeable p38 MAPK inhibitor (AB120638)

ab18528 staining Lamp2a in CaCO2 cells treated with SB 202190 (ab120638), by ICC/IF. Increase of Lamp2a expression correlates with increased concentration of SB 202190, as described in literature.
The cells were incubated at 37°C for 3 hours in media containing different concentrations of ab120638 (SB 202190) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18528 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - SB 202190, cell-permeable p38 MAPK inhibitor (AB120638)
  • Chemical Structure

Lab

Chemical Structure - SB 202190, cell-permeable p38 MAPK inhibitor (AB120638)

2D chemical structure image of ab120638, SB 202190, cell-permeable p38 MAPK inhibitor

Key facts

CAS number

152121-30-7

Purity

>99%

Form

Solid

form

Molecular weight

331.3 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>1</sub><sub>4</sub>FN<sub>3</sub>O

PubChem

5169

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole

Biological description

Highly selective, potent and cell-permeable p38 MAPK inhibitor (IC50 values are 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2, respectively). Selective over a wide range of other kinases. Apoptosis and autophagy inducer. 3D Growth matrix component and additive for long term growth; also component of gastric organoid culture media.

Canonical smiles

C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O

InChi

InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)

InChiKey

QHKYPYXTTXKZST-UHFFFAOYSA-N

IUPAC Name

4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Science advances 9:eadi1328 PubMed37756411

2023

Piezo1 activates noncanonical EGFR endocytosis and signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos Pardo-Pastor,Jody Rosenblatt

Glia 70:1850-1863 PubMed35635122

2022

CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Maria P Ivshina,Heleen M van 't Spijker,Suna Jung,Sithara Raju Ponny,Dorothy P Schafer,Joel D Richter

Frontiers in immunology 12:755862 PubMed34867992

2021

Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

João Paulo Silva Nunes,Pauline Andrieux,Pauline Brochet,Rafael Ribeiro Almeida,Eduardo Kitano,André Kenji Honda,Leo Kei Iwai,Débora Andrade-Silva,David Goudenège,Karla Deysiree Alcântara Silva,Raquel de Souza Vieira,Débora Levy,Sergio Paulo Bydlowski,Frédéric Gallardo,Magali Torres,Edimar Alcides Bocchi,Miguel Mano,Ronaldo Honorato Barros Santos,Fernando Bacal,Pablo Pomerantzeff,Francisco Rafael Martins Laurindo,Priscila Camillo Teixeira,Helder I Nakaya,Jorge Kalil,Vincent Procaccio,Christophe Chevillard,Edecio Cunha-Neto

Molecular oncology 15:1289-1307 PubMed33342034

2021

Anti-pyroptotic function of TGF-β is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yusuke Tamura,Masato Morikawa,Ryo Tanabe,Kohei Miyazono,Daizo Koinuma

Cell reports 24:987-1000.e7 PubMed30044993

2018

Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.

Applications

Unspecified application

Species

Unspecified reactive species

Eva-Maria Hock,Zuzanna Maniecka,Marian Hruska-Plochan,Stefan Reber,Florent Laferrière,Sonu Sahadevan M K,Helena Ederle,Lauren Gittings,Lucas Pelkmans,Luc Dupuis,Tammaryn Lashley,Marc-David Ruepp,Dorothee Dormann,Magdalini Polymenidou

Cellular signalling 49:1-16 PubMed29729335

2018

Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27.

Applications

Unspecified application

Species

Unspecified reactive species

Toshiaki Tanaka,Mitsuyoshi Iino,Kaoru Goto

Scientific reports 6:38616 PubMed27929080

2016

TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

George Coricor,Rosa Serra

International journal of molecular sciences 17: PubMed27690009

2016

CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Lu,Jia Shi,Jinming Zhang,Zhengtao Lv,Fengjing Guo,Hui Huang,Wentao Zhu,Anmin Chen

International journal of molecular sciences 17:159 PubMed26861294

2016

p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jan Šrámek,Vlasta Němcová-Fürstová,Kamila Balušíková,Petr Daniel,Michael Jelínek,Roger F James,Jan Kovář

Breast cancer research and treatment 138:741-52 PubMed23539298

2013

EZH2 inhibition decreases p38 signaling and suppresses breast cancer motility and metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Heather M Moore,Maria E Gonzalez,Kathy A Toy,Ashley Cimino-Mathews,Pedram Argani,Celina G Kleer
View all publications
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