MW 331.3 Da, Purity >99%. Highly selective, potent and cell-permeable p38 MAPK inhibitor (IC50 values are 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2, respectively). Selective over a wide range of other kinases. Apoptosis and autophagy inducer. 3D Growth matrix component and additive for long term growth; also component of gastric organoid culture media.
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- Science advances 9:eadi13282023Piezo1 activates noncanonical EGFR endocytosis and signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCarlos Pardo-Pastor,Jody RosenblattPubMed 37756411
- Glia 70:1850-18632022CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria P Ivshina,Heleen M van 't Spijker,Suna Jung,Sithara Raju Ponny,Dorothy P Schafer,Joel D RichterPubMed 35635122
- Frontiers in immunology 12:7558622021Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoão Paulo Silva Nunes,Pauline Andrieux,Pauline Brochet,Rafael Ribeiro Almeida,Eduardo Kitano,André Kenji Honda,Leo Kei Iwai,Débora Andrade-Silva,David Goudenège,Karla Deysiree Alcântara Silva,Raquel de Souza Vieira,Débora Levy,Sergio Paulo Bydlowski,Frédéric Gallardo,Magali Torres,Edimar Alcides Bocchi,Miguel Mano,Ronaldo Honorato Barros Santos,Fernando Bacal,Pablo Pomerantzeff,Francisco Rafael Martins Laurindo,Priscila Camillo Teixeira,Helder I Nakaya,Jorge Kalil,Vincent Procaccio,Christophe Chevillard,Edecio Cunha-NetoPubMed 34867992
- Molecular oncology 15:1289-13072021Anti-pyroptotic function of TGF-β is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYusuke Tamura,Masato Morikawa,Ryo Tanabe,Kohei Miyazono,Daizo KoinumaPubMed 33342034
- Cell reports 24:987-1000.e72018Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEva-Maria Hock,Zuzanna Maniecka,Marian Hruska-Plochan,Stefan Reber,Florent Laferrière,Sonu Sahadevan M K,Helena Ederle,Lauren Gittings,Lucas Pelkmans,Luc Dupuis,Tammaryn Lashley,Marc-David Ruepp,Dorothee Dormann,Magdalini PolymenidouPubMed 30044993
- Cellular signalling 49:1-162018Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27.Applications:Unspecified applicationReactive species:Unspecified reactive speciesToshiaki Tanaka et. al.PubMed 29729335
- Scientific reports 6:386162016TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGeorge Coricor et. al.PubMed 27929080
- International journal of molecular sciences 17:2016CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWeiwei Lu et. al.PubMed 27690009
- International journal of molecular sciences 17:1592016p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJan Šrámek et. al.PubMed 26861294
Key facts
- CAS number
- 152121-30-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 331.3 Da
- Molecular formula
- C20H14FN3O
- PubChem identifier
- 5169
- Nature
- Synthetic
Recommended products
MW 331.3 Da, Purity >99%. Highly selective, potent and cell-permeable p38 MAPK inhibitor (IC50 values are 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2, respectively). Selective over a wide range of other kinases. Apoptosis and autophagy inducer. 3D Growth matrix component and additive for long term growth; also component of gastric organoid culture media.
Key facts
- CAS number
- 152121-30-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 331.3 Da
- Molecular formula
- C20H14FN3O
- PubChem identifier
- 5169
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole
- Biological description
Highly selective, potent and cell-permeable p38 MAPK inhibitor (IC50 values are 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2, respectively). Selective over a wide range of other kinases. Apoptosis and autophagy inducer. 3D Growth matrix component and additive for long term growth; also component of gastric organoid culture media.
- Canonical SMILES
- C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O
- InChI
- InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
- InChIKey
- QHKYPYXTTXKZST-UHFFFAOYSA-N
- IUPAC name
- 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - SB 202190, cell-permeable p38 MAPK inhibitor (ab120638)
2D chemical structure image of ab120638, SB 202190, cell-permeable p38 MAPK inhibitor
Immunocytochemistry/ Immunofluorescence - SB 202190, cell-permeable p38 MAPK inhibitor (ab120638)
Anti-LAMP2A antibody - Lysosome Marker ab18528 staining Lamp2a in CaCO2 cells treated with SB 202190 (ab120638), by ICC/IF. Increase of Lamp2a expression correlates with increased concentration of SB 202190, as described in literature.
The cells were incubated at 37°C for 3 hours in media containing different concentrations of ab120638 (SB 202190) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-LAMP2A antibody - Lysosome Marker ab18528 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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