SB 203580 (DMSO solution), p38 MAPK inhibitor

Key facts

CAS number

152121-47-6

Purity

>98%

Form

Liquid

form

Molecular weight

377.4 Da

Molecular formula

C₂₁H₁₆FN₃OS

PubChem

176155

Nature

Synthetic

Biochemical name

4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

Biological description

Cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1, RIP2, c-Raf and GSK3.

Canonical smiles

CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

InChi

InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

InChiKey

CDMGBJANTYXAIV-UHFFFAOYSA-N

IUPAC Name

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine