SB 203580 hydrochloride, p38 MAPK inhibitor

Key facts

CAS number

869185-85-3

Purity

>98%

Form

Solid

form

Molecular weight

413.9 Da

Molecular formula

C₂₁H₁₇ClFN₃OS

PubChem

16760644

Nature

Synthetic

Solubility

Soluble in water to 25 mM

Biochemical name

SB 203580 Hydrochloride

Biological description

Water soluble, cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1 , RIP2 c-Raf and GSK3.

Canonical smiles

CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F.Cl

InChi

InChI=1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H

InChiKey

WOSGGXINSLMASH-UHFFFAOYSA-N

IUPAC Name

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine;hydrochloride