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MW 413.9 Da, Purity >98%. Water soluble, cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1 , RIP2 c-Raf and GSK3.

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Images

Chemical Structure - SB 203580 hydrochloride, p38 MAPK inhibitor (AB120235), expandable thumbnail

Publications

Key facts

CAS number
869185-85-3
Purity
> 98%
Form
Solid
Molecular weight
413.9 Da
Molecular formula
C21H17ClFN3OS
PubChem identifier
16760644
Nature
Synthetic

Target data

Recommended products

MW 413.9 Da, Purity >98%. Water soluble, cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1 , RIP2 c-Raf and GSK3.

Key facts

Purity
> 98%
PubChem identifier
16760644
Solubility

Soluble in water to 25 mM.

Biochemical name
SB 203580 Hydrochloride
Biological description

Water soluble, cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1 , RIP2 c-Raf and GSK3.

Canonical SMILES
CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F.Cl
InChI
InChI=1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H
InChIKey
WOSGGXINSLMASH-UHFFFAOYSA-N
IUPAC name
4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine;hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - SB 203580 hydrochloride, p38 MAPK inhibitor (ab120235), expandable thumbnail

    Chemical Structure - SB 203580 hydrochloride, p38 MAPK inhibitor (ab120235)

    2D chemical structure image of ab120235, SB 203580 hydrochloride, p38 MAPK inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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