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AB120162

SB 203580, p38 MAPK inhibitor

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(33 Publications)

MW 377.4 Da, Purity >99%. Achieve your results faster with highly validated, pure and trusted compounds.

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AI849689, BMK 1 kinase, BMK-1, Big MAP kinase 1, C Jun kinase 2, C-JUN kinase 1, CSAID Binding Protein 1, CSAID-binding protein, CSBP, CSBP 1, CSBP 2, CSPB1, Csaids binding protein, Cytokine suppressive anti-inflammatory drug-binding protein, EC 2.7.11.24, ERK-1, ERK-2, ERK-3, ERK-4, ERK-6, ERK-7, ERT 2, ERT1, EXIP, Erk3 related, Extracellular regulated kinase 8 delta, Extracellular signal regulated kinase p97, Extracellular signal related kinase 1, Extracellular signal-regulated kinase 1, Extracellular signal-regulated kinase 2, Extracellular signal-regulated kinase 3, Extracellular signal-regulated kinase 4, Extracellular signal-regulated kinase 5, Extracellular signal-regulated kinase 6, Extracellular signal-regulated kinase 7, Extracellular signal-regulated kinase 8, FLJ12099, FLJ33785, HGNC6877, HS44KDAP, HUMKER1A, HsT17250, Human p38Beta MAP kinase mRNA complete cds, Insulin-stimulated MAP2 kinase, JNK, JNK 1, JNK 2, JNK-46, JNK-55, JNK1A2, JNK2 alpha, JNK2 beta, JNK21B1/2, JNK2A, JNK2B, JNK3, JNK3 alpha protein kinase, JNK3A, Jun kinase, MAP Kinase, MAP kinase 1, MAP kinase 10, MAP kinase 11, MAP kinase 12, MAP kinase 13, MAP kinase 14, MAP kinase 15, MAP kinase 2, MAP kinase 3, MAP kinase 4, MAP kinase 6, MAP kinase 7, MAP kinase 8, MAP kinase 9, MAP kinase MXI2, MAP kinase isoform p42, MAP kinase isoform p44, MAP kinase isoform p63, MAP kinase isoform p97, MAP kinase p38 alpha, MAP kinase p38 beta, MAP kinase p38 delta, MAP kinase p38 gamma, MAP kinase p49 3F12, MAPK, MAPK 1, MAPK 10, MAPK 11, MAPK 12, MAPK 14, MAPK 15, MAPK 6, MAPK 7, MAPK 8, MAPK 9, MAPK-13, MAX-interacting protein 2, MGC20180, MGC50974, MGC99536, MK01_HUMAN, MK03_HUMAN, MK04_HUMAN, MK06_HUMAN, MK07_HUMAN, MK08_HUMAN, MK09_HUMAN, MK10_HUMAN, MK11_HUMAN, MK12_HUMAN, MK13_HUMAN, MK14_HUMAN, MK15_HUMAN, Microtubule-associated protein 2 kinase, Mitogen activated protein kinase p38 2, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 11, Mitogen-activated protein kinase 12, Mitogen-activated protein kinase 13, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 15, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 4, Mitogen-activated protein kinase 6, Mitogen-activated protein kinase 7, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase p38 alpha, Mitogen-activated protein kinase p38 beta, Mitogen-activated protein kinase p38 delta, Mitogen-activated protein kinase p38 gamma, Mxi 2, OTTHUMP00000016282, OTTHUMP00000016283, OTTHUMP00000065906, OTTHUMP00000065907, OTTHUMP00000174538, OTTHUMP00000174541, P38, P38 GAMMA, P38BETA2, P41, P54a, PRKM 2, PRKM 3, PRKM 7, PRKM 8, PRKM 9, PRKM1, PRKM10, PRKM11, PRKM12, PRKM13, PRKM14, PRKM15, PRKM4, PRKM6, PROTEIN KINASE MITOGEN-ACTIVATED 7, Protein Kinase Mitogen Activated 3, Protein kinase JNK1, Protein kinase mitogen activated 11, Protein kinase mitogen activated 5, Protein kinase mitogen activated 6, Protein kinase mitogen-activated 4, Protein kinase mitogen-activated 8, Protein kinase mitogen-activated 9, Protein-tyrosine kinase ERK3-related, RK, RMNK2, SAPK, SAPK 1, SAPK 4, SAPK alpha, SAPK gamma, SAPK-3, SAPK1a, SAPK1b, SAPK2, SAPK2A, SAPK2B, Stress activated protein kinase 2b, Stress activated protein kinase beta, Stress-activated protein kinase 1, Stress-activated protein kinase 1a, Stress-activated protein kinase 1b, Stress-activated protein kinase 2, Stress-activated protein kinase 2a, Stress-activated protein kinase 3, Stress-activated protein kinase 4, Stress-activated protein kinase JNK1, Stress-activated protein kinase JNK2, Stress-activated protein kinase JNK3, c Jun kinase 3, c-Jun N-terminal kinase 1, c-Jun N-terminal kinase 2, c-Jun N-terminal kinase 3, p38 ALPHA, p38 MAP kinase, p38 MAPK, p38 delta, p38 mitogen activated protein kinase, p38-2, p38B, p38Beta, p38alpha Exip, p42-MAPK, p44-ERK1, p44-MAPK, p493F12, p54 gamma, p54aSAPK, p54bSAPK, p63-MAPK, p97-MAPK, protein kinase mitogen activated 10, protein kinase mitogen-activated 1, protein kinase mitogen-activated 2, protein tyrosine kinase ERK2

1 Images
Chemical Structure - SB 203580, p38 MAPK inhibitor (AB120162)
  • Chemical Structure

Lab

Chemical Structure - SB 203580, p38 MAPK inhibitor (AB120162)

2D chemical structure image of ab120162, SB 203580, p38 MAPK inhibitor

Key facts

CAS number

152121-47-6

Purity

>99%

Form

Solid

form

Molecular weight

377.4 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>1</sub><sub>6</sub>FN<sub>3</sub>OS

PubChem

176155

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

Canonical smiles

CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

InChi

InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

InChiKey

CDMGBJANTYXAIV-UHFFFAOYSA-N

IUPAC Name

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MAPK family including p38 JNK1 ERK1 ERK2 and others like MAPK12 (p38 gamma) MAPK11 (p38 beta) and ERK8 function as serine/threonine kinases. These proteins are essential in cellular signaling. The average molecular mass of these kinases ranges from 40 to 60 kDa. They are expressed in various tissues such as liver lung and brain highlighting their diverse roles in different cell types and conditions.
Biological function summary

Kinases like p38 and its related MAPK members are involved in cellular responses to stress and cytokines playing critical roles in inflammation and apoptosis. These proteins participate in large signaling complexes formed with scaffolding and regulatory proteins amplifying the transmission of environmental signals into the cell. The well-studied p38 pathway influences cellular differentiation especially in response to external stimuli.

Pathways

P38 kinases and other MAPK members integrate into the MAPK/ERK and JNK signaling frameworks. These pathways influence cellular processes such as growth and apoptosis. For instance p38 and JNK1 interact with transcription factors like AP-1 and proteins such as MEK1/2 within these pathways regulating gene expression in response to signals for maintaining cellular homeostasis.

P38 kinases and related MAPK proteins play roles in conditions like rheumatoid arthritis and neurodegenerative diseases. Their involvement in inflammatory pathways associates them with the pathological mechanisms of these diseases. Particularly MAPK12 (p38 gamma) and JNK3 are investigated for their roles in neuronal death and inflammation linking these kinases to potential therapeutic targets for diseases characterized by excessive inflammation or cell damage.

Product protocols

Publications (33)

Recent publications for all applications. Explore the full list and refine your search

Drug design, development and therapy 19:2433-2452 PubMed40190807

2025

Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload.

Applications

Unspecified application

Species

Unspecified reactive species

Xi-Xi Hou,Shuang Wang,Xiao-Xia Ma,Ying Wen,Zhi-Jun Li,Xu-Yun Liu,Xing Zhang,Yang Zhang,Xiang-Yang Qin

EMBO reports 25:3456-3485 PubMed38877170

2024

ABIN1 is a negative regulator of effector functions in cytotoxic T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sarka Janusova,Darina Paprckova,Juraj Michalik,Valeria Uleri,Ales Drobek,Eva Salyova,Louise Chorfi,Ales Neuwirth,Arina Andreyeva,Jan Prochazka,Radislav Sedlacek,Peter Draber,Ondrej Stepanek

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2400611 PubMed38873823

2024

CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Wang,Xiaohong Chen,Peng Lin,Jiao Wu,Qiang Huang,Zhi-Nan Chen,Jiale Tian,Hao Wang,Ye Tian,Mingyan Shi,Meirui Qian,Bengang Hui,Yumeng Zhu,Ling Li,Rui Yao,Huijie Bian,Ping Zhu,Ruo Chen,Liang Chen

British journal of pharmacology 180:3271-3289 PubMed37547998

2023

A novel small molecule inhibitor of p38⍺ MAP kinase augments cardiomyocyte cell cycle entry in response to direct cell cycle stimulation.

Applications

Unspecified application

Species

Unspecified reactive species

Riham R E Abouleisa,Jessica M Miller,Ahmad Gebreil,Abou Bakr M Salama,Marc Dwenger,Hania Abdelhafez,Reham M Wahid,Adeniyi T Adewumi,Mahmoud E S Soliman,Nader E Abo-Dya,Tamer M A Mohamed

Oncology letters 25:144 PubMed36936027

2023

PSKH1 affects proliferation and invasion of osteosarcoma cells via the p38/MAPK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xingfei Zhu,Chao Jiang,Zhiyuang Wang,Xiaozhong Zhu,Feng Yuan,Yi Yang

Antioxidants (Basel, Switzerland) 12: PubMed36671037

2023

Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xuyun Liu,Jing Gao,Yizhen Yan,Eleftheria A Georgiou,Jing Lou,Mengya Feng,Xing Zhang,Feng Gao,Jiankang Liu,Ioannis K Kostakis,Lin Zhao

Frontiers in oncology 12:911615 PubMed35712465

2022

Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Halima Alsamri,Aysha Alneyadi,Khalid Muhammad,Mohammed Akli Ayoub,Ali Eid,Rabah Iratni

Frontiers in microbiology 13:834091 PubMed35422784

2022

Estrogen Suppresses Cytokines Release in cc4821 Infection TLR4 and ERβ-p38-MAPK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Pengbo Guo,Juan Xu,Hao Liang,Li Xu,Wanying Gao,Ziman Chen,Yuan Gao,Maojun Zhang,Guangfu Yu,Zhujun Shao

Molecular medicine reports 24: PubMed34590154

2021

MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Chun-Na Lan,Wei-Jun Cai,Jie Shi,Zhong-Jie Yi

Journal of neuroinflammation 18:150 PubMed34225736

2021

Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3.

Applications

Unspecified application

Species

Unspecified reactive species

Hao-Nan Li,Qing-Qing Yang,Wen-Tao Wang,Xue Tian,Fan Feng,Shu-Ting Zhang,Yu-Tong Xia,Jia-Xue Wang,Yuan-Wu Zou,Jun-Yang Wang,Xiao-Yan Zeng
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