SB 203580, p38 MAPK inhibitor
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(33 Publications)
MW 377.4 Da, Purity >99%. Achieve your results faster with highly validated, pure and trusted compounds.
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AI849689, BMK 1 kinase, BMK-1, Big MAP kinase 1, C Jun kinase 2, C-JUN kinase 1, CSAID Binding Protein 1, CSAID-binding protein, CSBP, CSBP 1, CSBP 2, CSPB1, Csaids binding protein, Cytokine suppressive anti-inflammatory drug-binding protein, EC 2.7.11.24, ERK-1, ERK-2, ERK-3, ERK-4, ERK-6, ERK-7, ERT 2, ERT1, EXIP, Erk3 related, Extracellular regulated kinase 8 delta, Extracellular signal regulated kinase p97, Extracellular signal related kinase 1, Extracellular signal-regulated kinase 1, Extracellular signal-regulated kinase 2, Extracellular signal-regulated kinase 3, Extracellular signal-regulated kinase 4, Extracellular signal-regulated kinase 5, Extracellular signal-regulated kinase 6, Extracellular signal-regulated kinase 7, Extracellular signal-regulated kinase 8, FLJ12099, FLJ33785, HGNC6877, HS44KDAP, HUMKER1A, HsT17250, Human p38Beta MAP kinase mRNA complete cds, Insulin-stimulated MAP2 kinase, JNK, JNK 1, JNK 2, JNK-46, JNK-55, JNK1A2, JNK2 alpha, JNK2 beta, JNK21B1/2, JNK2A, JNK2B, JNK3, JNK3 alpha protein kinase, JNK3A, Jun kinase, MAP Kinase, MAP kinase 1, MAP kinase 10, MAP kinase 11, MAP kinase 12, MAP kinase 13, MAP kinase 14, MAP kinase 15, MAP kinase 2, MAP kinase 3, MAP kinase 4, MAP kinase 6, MAP kinase 7, MAP kinase 8, MAP kinase 9, MAP kinase MXI2, MAP kinase isoform p42, MAP kinase isoform p44, MAP kinase isoform p63, MAP kinase isoform p97, MAP kinase p38 alpha, MAP kinase p38 beta, MAP kinase p38 delta, MAP kinase p38 gamma, MAP kinase p49 3F12, MAPK, MAPK 1, MAPK 10, MAPK 11, MAPK 12, MAPK 14, MAPK 15, MAPK 6, MAPK 7, MAPK 8, MAPK 9, MAPK-13, MAX-interacting protein 2, MGC20180, MGC50974, MGC99536, MK01_HUMAN, MK03_HUMAN, MK04_HUMAN, MK06_HUMAN, MK07_HUMAN, MK08_HUMAN, MK09_HUMAN, MK10_HUMAN, MK11_HUMAN, MK12_HUMAN, MK13_HUMAN, MK14_HUMAN, MK15_HUMAN, Microtubule-associated protein 2 kinase, Mitogen activated protein kinase p38 2, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 11, Mitogen-activated protein kinase 12, Mitogen-activated protein kinase 13, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 15, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 4, Mitogen-activated protein kinase 6, Mitogen-activated protein kinase 7, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase p38 alpha, Mitogen-activated protein kinase p38 beta, Mitogen-activated protein kinase p38 delta, Mitogen-activated protein kinase p38 gamma, Mxi 2, OTTHUMP00000016282, OTTHUMP00000016283, OTTHUMP00000065906, OTTHUMP00000065907, OTTHUMP00000174538, OTTHUMP00000174541, P38, P38 GAMMA, P38BETA2, P41, P54a, PRKM 2, PRKM 3, PRKM 7, PRKM 8, PRKM 9, PRKM1, PRKM10, PRKM11, PRKM12, PRKM13, PRKM14, PRKM15, PRKM4, PRKM6, PROTEIN KINASE MITOGEN-ACTIVATED 7, Protein Kinase Mitogen Activated 3, Protein kinase JNK1, Protein kinase mitogen activated 11, Protein kinase mitogen activated 5, Protein kinase mitogen activated 6, Protein kinase mitogen-activated 4, Protein kinase mitogen-activated 8, Protein kinase mitogen-activated 9, Protein-tyrosine kinase ERK3-related, RK, RMNK2, SAPK, SAPK 1, SAPK 4, SAPK alpha, SAPK gamma, SAPK-3, SAPK1a, SAPK1b, SAPK2, SAPK2A, SAPK2B, Stress activated protein kinase 2b, Stress activated protein kinase beta, Stress-activated protein kinase 1, Stress-activated protein kinase 1a, Stress-activated protein kinase 1b, Stress-activated protein kinase 2, Stress-activated protein kinase 2a, Stress-activated protein kinase 3, Stress-activated protein kinase 4, Stress-activated protein kinase JNK1, Stress-activated protein kinase JNK2, Stress-activated protein kinase JNK3, c Jun kinase 3, c-Jun N-terminal kinase 1, c-Jun N-terminal kinase 2, c-Jun N-terminal kinase 3, p38 ALPHA, p38 MAP kinase, p38 MAPK, p38 delta, p38 mitogen activated protein kinase, p38-2, p38B, p38Beta, p38alpha Exip, p42-MAPK, p44-ERK1, p44-MAPK, p493F12, p54 gamma, p54aSAPK, p54bSAPK, p63-MAPK, p97-MAPK, protein kinase mitogen activated 10, protein kinase mitogen-activated 1, protein kinase mitogen-activated 2, protein tyrosine kinase ERK2
- Chemical Structure
Lab
Chemical Structure - SB 203580, p38 MAPK inhibitor (AB120162)
2D chemical structure image of ab120162, SB 203580, p38 MAPK inhibitor
Properties and storage information
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Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Kinases like p38 and its related MAPK members are involved in cellular responses to stress and cytokines playing critical roles in inflammation and apoptosis. These proteins participate in large signaling complexes formed with scaffolding and regulatory proteins amplifying the transmission of environmental signals into the cell. The well-studied p38 pathway influences cellular differentiation especially in response to external stimuli.
Pathways
P38 kinases and other MAPK members integrate into the MAPK/ERK and JNK signaling frameworks. These pathways influence cellular processes such as growth and apoptosis. For instance p38 and JNK1 interact with transcription factors like AP-1 and proteins such as MEK1/2 within these pathways regulating gene expression in response to signals for maintaining cellular homeostasis.
Publications (33)
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Drug design, development and therapy 19:2433-2452 PubMed40190807
2025
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EMBO reports 25:3456-3485 PubMed38877170
2024
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2400611 PubMed38873823
2024
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British journal of pharmacology 180:3271-3289 PubMed37547998
2023
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Oncology letters 25:144 PubMed36936027
2023
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Antioxidants (Basel, Switzerland) 12: PubMed36671037
2023
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Frontiers in oncology 12:911615 PubMed35712465
2022
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Frontiers in microbiology 13:834091 PubMed35422784
2022
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Molecular medicine reports 24: PubMed34590154
2021
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Journal of neuroinflammation 18:150 PubMed34225736
2021
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Product promise
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