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AB120519

SB 242084 hydrochloride, 5-HT2C antagonist

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(1 Publication)

MW 431.3 Da, Purity >98%. Potent, selective 5-HT2C antagonist (pKi values are 9 (5-HT2C), 7 (5-HT2B), 6.8 (5-HT2A), 6.4 (5-HT1A), 6.4 (5-HT1B), 6.4 (5-HT1D), 6 (5-HT1E), <6.1 (5-HT1F), <5.5 (5-HT4), 6 (5-HT6), 6.1 (5-HT7), 6.2 (D2), 6.2 (D3) and <5 (α1)). Blood-brain barrier permeable. Anxiolytic activity *in vivo*.
1 Images
Chemical Structure - SB 242084 hydrochloride, 5-HT2C antagonist (AB120519)
  • Chemical Structure

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Chemical Structure - SB 242084 hydrochloride, 5-HT2C antagonist (AB120519)

2D chemical structure image of ab120519, SB 242084 hydrochloride, 5-HT2C antagonist

Key facts

CAS number

1260505-34-7

Purity

>98%

Form

Solid

form

Molecular weight

431.3 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>0</sub>Cl<sub>2</sub>N<sub>4</sub>O<sub>2</sub>

PubChem

72201049

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

SB 242084 hydrochloride

Biological description

Potent, selective 5-HT2C antagonist (pKi values are 9 (5-HT2C), 7 (5-HT2B), 6.8 (5-HT2A), 6.4 (5-HT1A), 6.4 (5-HT1B), 6.4 (5-HT1D), 6 (5-HT1E), <6.1 (5-HT1F), <5.5 (5-HT4), 6 (5-HT6), 6.1 (5-HT7), 6.2 (D2), 6.2 (D3) and <5 (α1)). Blood-brain barrier permeable. Anxiolytic activity *in vivo*.

Canonical smiles

CC1=CC2=C(C=C1Cl)N(CC2)C(=O)NC3=CN=C(C=C3)OC4=C(N=CC=C4)C.Cl

InChi

InChI=1S/C21H19ClN4O2.ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);1H

InChiKey

WOKOGXKQXNESDA-UHFFFAOYSA-N

IUPAC Name

6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

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The Journal of pharmacology and experimental therapeutics 364:359-366 PubMed29217539

2017

Inhibition of Cocaine and 3,4-Methylenedioxypyrovalerone (MDPV) Self-Administration by Lorcaserin Is Mediated by 5-HT2C Receptors in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Brenda M Gannon,Agnieszka Sulima,Kenner C Rice,Gregory T Collins
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