SB 243213 dihydrochloride, 5HT2C receptor antagonist
Be the first to review this product! Submit a review
|
(0 Publication)
MW 464.9 Da, Purity >99%. Potent, selective 5-HT2C receptor antagonist (Ki = 1 nM). Neurological agent. Active *in vivo* and *in vitro*.
View Alternative Names
AIS, ANDR_HUMAN, AR, AR8, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Atherosclerosis, susceptibility to, included, BXR, DHTR, DKFZp686N23123, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen-related receptor alpha, Estrra, HDL cholesterol, augmented response of, to hormone replacement, included, HUMARA, HYSP1, KD, Kennedy disease (KD), Myocardial infarction, susceptibility to, included, NF-E2-related factor 2, NF2L2_HUMAN, NR1I2_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, PAR, PAR q, PRR, Pregnane X receptor, RNESTROR, SBMA, SMAX1, SXR, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, Testicular Feminization (TFM), androgen receptor splice variant 4b, erythroid derived 2, estrogen receptor related receptor alpha, hERR1, like 2, nuclear factor erythroid 2 like 2, pregnane X nuclear receptor variant 2
- Chemical Structure
Lab
Chemical Structure - SB 243213 dihydrochloride, 5HT2C receptor antagonist (AB141291)
2D chemical structure image of ab141291, SB 243213 dihydrochloride, 5HT2C receptor antagonist
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These receptors and transcription factors orchestrate significant molecular functions. ER and AR modulate gene transcription upon binding their respective ligands estrogen and testosterone. Part of their function includes forming complexes with other co-regulators. PXR integrates metabolism-related gene expression impacting drug metabolism by forming a regulatory network with other nuclear receptors. ERRα influences mitochondrial biogenesis and function integrating energy homeostasis. Nrf2 responds to oxidative stress by dissociating from Keap1 then translocating to the nucleus to activate antioxidant response elements (ARE).
Pathways
ER and AR are integral to hormone signaling pathways. ER interacts within the estrogen-signaling pathway influencing proteins such as coactivators and corepressors. AR is active in the androgen receptor signaling pathway involving direct androgenic signaling and crosstalk with other pathways such as the Wnt signaling pathway. PXR plays a role in the nuclear receptor signaling pathways related to xenobiotic metabolism which involves the CYP3A4 enzyme and impacts detoxification processes. ERRα is linked to pathways regulating cellular energy metabolism interacting with proteins such as PGC-1α. Nrf2 fits into the KEAP1-NRF2-ARE pathway essential for mediating the antioxidant response.
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com