MW 389 Da, Purity >98%. Potent, selective 5-HT7 receptor antagonist (pKi values are 8.3, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B receptors, respectively). Also potently blocks α2 adrenoceptors. Blocks amphetamine and ketamine induced hyperactivity. Brain penetrant *in vivo*.
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- Neuropsychopharmacology : official publication of 45:2267-22772020Implication of 5-HT7 receptor in prefrontal circuit assembly and detrimental emotional effects of SSRIs during development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJimmy Olusakin et. al.PubMed 32688364
- The Journal of allergy and clinical immunology 142:1349-1352.e162018Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSang Hoon Lee et. al.PubMed 29920354
Key facts
- CAS number
- 261901-57-9
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 389 Da
- Molecular formula
- C18H29ClN2O3S
- PubChem identifier
- 11957684
- Nature
- Synthetic
Recommended products
MW 389 Da, Purity >98%. Potent, selective 5-HT7 receptor antagonist (pKi values are 8.3, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B receptors, respectively). Also potently blocks α2 adrenoceptors. Blocks amphetamine and ketamine induced hyperactivity. Brain penetrant *in vivo*.
Key facts
- CAS number
- 261901-57-9
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 389 Da
- Molecular formula
- C18H29ClN2O3S
- PubChem identifier
- 11957684
- Nature
- Synthetic
- Solubility
Soluble in water to 50 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- (R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride
- Biological description
Potent, selective 5-HT7 receptor antagonist (pKi values are 8.3, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B receptors, respectively). Also potently blocks α2 adrenoceptors. Blocks amphetamine and ketamine induced hyperactivity. Brain penetrant *in vivo*.
- Canonical SMILES
- CC1CCN(CC1)CCC2CCCN2S(=O)(=O)C3=CC=CC(=C3)O.Cl
- Isomeric SMILES
- CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)C3=CC=CC(=C3)O.Cl
- InChI
- InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
- InChIKey
- XQCJOYZLWFNDIO-PKLMIRHRSA-N
- IUPAC name
- 3-[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidin-1-yl]sulfonylphenol;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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1 product image
Chemical Structure - SB 269970 hydrochloride, 5-HT7 receptor antagonist (ab120508)
2D chemical structure image of ab120508, SB 269970 hydrochloride, 5-HT7 receptor antagonist
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