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AB120567

SB-277011-A dihydrochloride, D3 antagonist

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(1 Publication)

MW 511.5 Da, Purity >98%. Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.
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Chemical Structure - SB-277011-A dihydrochloride, D3 antagonist (AB120567)
  • Chemical Structure

Lab

Chemical Structure - SB-277011-A dihydrochloride, D3 antagonist (AB120567)

2D chemical structure image of ab120567, SB-277011-A dihydrochloride, D3 antagonist

Key facts

CAS number

1226917-67-4

Purity

>98%

Form

Solid

form

Molecular weight

511.5 Da

Molecular formula

C<sub>2</sub><sub>8</sub>H<sub>3</sub><sub>2</sub>Cl<sub>2</sub>N<sub>4</sub>O

PubChem

75358288

Nature

Synthetic

Solubility

Soluble in water to 10 mM

Soluble in ethanol to 10 mM

Soluble in DMSO to 100 mM

Biochemical name

SB 277011A dihydrochloride

Biological description

Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.

Canonical smiles

C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45.Cl.Cl

InChi

InChI=1S/C28H30N4O.2ClH/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);2*1H

InChiKey

HEZIOTGUXSPDAK-UHFFFAOYSA-N

IUPAC Name

N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide;dihydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neuroscience 406:376-388 PubMed30910641

2019

Dopamine D1 and D3 receptor modulators restore morphine analgesia and prevent opioid preference in a model of neuropathic pain.

Applications

Unspecified application

Species

Unspecified reactive species

H M Rodgers,J Yow,E Evans,S Clemens,Kori L Brewer
View all publications
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