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MW 511.5 Da, Purity >98%. Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.

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Chemical Structure - SB-277011-A dihydrochloride, D3 antagonist (AB120567), expandable thumbnail

Publications

Key facts

CAS number
1226917-67-4
Purity
> 98%
Form
Solid
Molecular weight
511.5 Da
Molecular formula
C28H32Cl2N4O
PubChem identifier
75358288
Nature
Synthetic

Target data

Recommended products

MW 511.5 Da, Purity >98%. Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.

Key facts

Purity
> 98%
PubChem identifier
75358288
Solubility

Soluble in water to 10 mM.

Soluble in ethanol to 10 mM.

Soluble in DMSO to 100 mM.

Biochemical name
SB 277011A dihydrochloride
Biological description

Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.

Canonical SMILES
C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45.Cl.Cl
InChI
InChI=1S/C28H30N4O.2ClH/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);2*1H
InChIKey
HEZIOTGUXSPDAK-UHFFFAOYSA-N
IUPAC name
N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide;dihydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - SB-277011-A dihydrochloride, D3 antagonist (ab120567), expandable thumbnail

    Chemical Structure - SB-277011-A dihydrochloride, D3 antagonist (ab120567)

    2D chemical structure image of ab120567, SB-277011-A dihydrochloride, D3 antagonist

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Product protocols

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