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AB120821

SB 297006, CCR3 antagonist

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(1 Publication)

MW 342.35 g/mol, Purity >99%. Highly potent, selective CCR3 antagonist (IC50 = 2.5 μM). Displays 250-fold selectivity for CCR3 vs. CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC50 values are 210, 90 and 80 nM, respectively).
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Chemical Structure - SB 297006, CCR3 antagonist (AB120821)
  • Chemical Structure

Lab

Chemical Structure - SB 297006, CCR3 antagonist (AB120821)

2D chemical structure image of ab120821, SB 297006, CCR3 antagonist

Key facts

CAS number

58816-69-6

Purity

>99%

Form

Solid

form

Molecular weight

342.35 g/mol

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>8</sub>N<sub>2</sub>O<sub>5</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 25 mM

Biological description

Highly potent, selective CCR3 antagonist (IC50 = 2.5 μM). Displays 250-fold selectivity for CCR3 vs. CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC50 values are 210, 90 and 80 nM, respectively).

IUPAC Name

N-Benzoyl-4-nitro-L-phenylalanine ethyl ester

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 8:207 PubMed28458639

2017

CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiki Kuse,Kazuhiro Tsuruma,Yusuke Kanno,Masamitsu Shimazawa,Hideaki Hara
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