MW 306.4 Da, Purity >98%. Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (Ki values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (Ki values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM). Neuroprotective and blood-brain barrier permeable.
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- Science advances 9:eadd92752023How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMario C Benn,Simon A Pot,Jens Moeller,Tadahiro Yamashita,Charlotte M Fonta,Gertraud Orend,Philip Kollmannsberger,Viola VogelPubMed 36989370
- Biophysical journal 114:650-6622018MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSandeep Kumar,Alakesh Das,Amlan Barai,Shamik SenPubMed 29414711
- Annals of Indian Academy of Neurology 17:171-82014Cerebrospinal fluid cytokines and matrix metalloproteinases in human immunodeficiency seropositive and seronegative patients of tuberculous meningitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDheeraj Rai,Ravindra Kumar Garg,Abbas Ali Mahdi,Amita Jain,Rajesh Verma,Anil Kumar Tripathi,Maneesh Kumar Singh,Hardeep Singh Malhotra,Gyan Prakash Singh,Mohammad Kaleem AhmadPubMed 25024567
Key facts
- CAS number
- 292605-14-2
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 306.4 Da
- Molecular formula
- C15H14O3S2
- PubChem identifier
- 9883002
- Nature
- Synthetic
Alternative names
72 kDa gelatinase, 72kD type IV collagenase, 82 kDa matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, CLG 4, CLG 4A, CLG 4B, Collagenase Type 4 alpha, Collagenase Type 4 beta, Collagenase type IV 92 KD, Collagenase type IV A, EC 3.4.24.35, GELB, Gelatinase 92 KD, Gelatinase A, Gelatinase B, Gelatinase alpha, Gelatinase beta, Gelatinase neutrophil, MANDP2, MMP II, MMP-X1, MMP14_HUMAN, MMP2_HUMAN, MMP9_HUMAN, MONA, MT-MMP 1, MT1-MMP, Macrophage gelatinase, Matrix Metalloproteinase 9, Matrix metallopeptidase 14 (membrane inserted), Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase, Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), Matrix metalloproteinase II, Matrix metalloproteinase-14, Matrix metalloproteinase-2, Membrane type 1 metalloprotease, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase, Neutrophil gelatinase, PEX, TBE-1, Type V collagenase
Recommended products
MW 306.4 Da, Purity >98%. Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (Ki values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (Ki values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM). Neuroprotective and blood-brain barrier permeable.
Key facts
- CAS number
- 292605-14-2
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 306.4 Da
- Molecular formula
- C15H14O3S2
- PubChem identifier
- 9883002
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 25 mM.
Soluble in ethanol.
- Biochemical name
- 2-[(4-Phenoxyphenyl)sulfonylmethyl]thiirane
- Biological description
Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (Ki values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (Ki values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM). Neuroprotective and blood-brain barrier permeable.
- Canonical SMILES
- C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3
- InChI
- InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
- InChIKey
- LSONWRHLFZYHIN-UHFFFAOYSA-N
- IUPAC name
- 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MMP14 also known as MT1-MMP MMP2 and MMP9 are enzymes in the matrix metalloproteinase (MMP) family which are zinc-dependent endopeptidases. They play major role in degrading extracellular matrix proteins. MMP14 has a molecular mass of about 66 kDa and is expressed in various tissues including the brain and connective tissues. MMP2 often referred as gelatinase A weighs approximately 72 kDa while MMP9 or gelatinase B is around 92 kDa. Both MMP2 and MMP9 appear in many cell types like macrophages neutrophils and fibroblasts. Their expression promotes tissue remodeling and repair.
- Biological function summary
MMP14 MMP2 and MMP9 are significant in matrix remodeling processes. These proteins can form active complexes in presence of TIMPs (tissue inhibitors of metalloproteinases) regulating their activity. They break down not just structural proteins in extracellular matrix but also bioactive molecules impacting cellular functions such as migration invasion and angiogenesis. This biological activity of MMPs is critical in both physiological development and pathological processes.
- Pathways
MMP14 MMP2 and MMP9 contribute significantly to the ECM-receptor interaction pathway and the PI3K-AKT signaling pathway. These pathways influence cell survival proliferation and migration. Additionally they relate to proteins like TIMP1 and TIMP2 that regulate their enzymatic activity. By integrating these pathways MMPs sustain important mechanisms in tissue homeostasis and pathological conditions such as tissue fibrosis and cancer progression.
- Associated diseases and disorders
MMP14 MMP2 and MMP9 have strong associations with cancer and arthritis. These enzymes facilitate cancer invasion and metastasis by degrading surrounding tissue barriers often seen in a range of tumorigenic processes. In arthritis particularly rheumatoid arthritis their imbalance leads to enhanced cartilage degradation. Connecting to this role in disease are proteins like cytokines and growth factors that induce MMP expression further implicating them in disease etiology and progression.
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Chemical Structure - SB-3CT, MMP-2 and MMP-9 inhibitor (ab141579)
2D chemical structure image of ab141579, SB-3CT, MMP-2 and MMP-9 inhibitor
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