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AB120163

SB431542, ALK inhibitor

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(51 Publications)

SB431542, ALK inhibitor (CAS: 301836-41-9)(ab120163) is a potent and selective inhibitor of Activin receptor-like kinase (ALK). Molecular weight of SB431542 is 384.4 g/mol.

- Inhibits ALK 4, 5 (IC50 = 94 nM), and 7
- Available in different formats to fit your experimental needs. Larger volume format available upon request
1 Images
Chemical Structure - SB431542, ALK inhibitor (AB120163)
  • Chemical Structure

Lab

Chemical Structure - SB431542, ALK inhibitor (AB120163)

2D chemical structure image of ab120163, SB431542, ALK inhibitor

Key facts

CAS number

301836-41-9

Purity

>99%

Form

Solid

form

Molecular weight

384.4 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>1</sub><sub>6</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

4521392

Nature

Synthetic

Biochemical name

4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide

Biological description

Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.

Canonical smiles

C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

InChi

InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)

InChiKey

FHYUGAJXYORMHI-UHFFFAOYSA-N

IUPAC Name

4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB32454

Anti-MAP2 antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-MAP2 antibody - Neuronal Marker (AB32454)

  • 5
  • 35
Primary Antibodies

AB97959

Anti-SOX2 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX2 antibody (AB97959)

  • 4
  • 76
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Product details

SB431542, ALK inhibitor (ab120163) is a potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors 4, 5 and 7.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (51)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 15:7127-7153 PubMed40585989

2025

FAK signaling suppression by OCT4-ITGA6 mediates the effectively removal of residual pluripotent stem cells and enhances application safety.

Applications

Unspecified application

Species

Unspecified reactive species

Wenpeng Song,Jian Wang,Shixin Gong,Xiaoyan Wang,Junji Xu,Ruiqing Wu,Zongmin Jiang,Huiyuan Zhang,Lida Wu,Yilong Wang,Yingying Su,Hao Wang,Yuchun Gu

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2409040 PubMed40245004

2025

α-Synuclein Pathology Spreads in a Midbrain-Hindbrain Assembloid Model.

Applications

Unspecified application

Species

Unspecified reactive species

Gemma Gomez-Giro,Daniela Frangenberg,Daniela Vega,Alise Zagare,Kyriaki Barmpa,Paul M A Antony,Graham Robertson,Rahman Sabahi-Kaviani,Kristian Haendler,Nathalie Kruse,Florentia Papastefanaki,Rebecca Matsas,Malte Spielmann,Regina Luttge,Jens C Schwamborn

Communications biology 7:1561 PubMed39580573

2024

Modeling early phenotypes of Parkinson's disease by age-induced midbrain-striatum assembloids.

Applications

Unspecified application

Species

Unspecified reactive species

Kyriaki Barmpa,Claudia Saraiva,Diego Lopez-Pigozzi,Gemma Gomez-Giro,Elisa Gabassi,Sarah Spitz,Konstanze Brandauer,Juan E Rodriguez Gatica,Paul Antony,Graham Robertson,Rahman Sabahi-Kaviani,Alessandro Bellapianta,Florentia Papastefanaki,Regina Luttge,Ulrich Kubitscheck,Ahmad Salti,Peter Ertl,Mario Bortolozzi,Rebecca Matsas,Frank Edenhofer,Jens C Schwamborn

Molecular medicine (Cambridge, Mass.) 30:227 PubMed39578767

2024

Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model.

Applications

Unspecified application

Species

Unspecified reactive species

Yiwen Yao,Felix Ritzmann,Sarah Miethe,Kathrin Kattler-Lackes,Betül Colakoglu,Christian Herr,Andreas Kamyschnikow,Michelle Brand,Holger Garn,Daniela Yildiz,Frank Langer,Robert Bals,Christoph Beisswenger

Nature methods 22:68-81 PubMed39300283

2024

Gene-level alignment of single-cell trajectories.

Applications

Unspecified application

Species

Unspecified reactive species

Dinithi Sumanaweera,Chenqu Suo,Ana-Maria Cujba,Daniele Muraro,Emma Dann,Krzysztof Polanski,Alexander S Steemers,Woochan Lee,Amanda J Oliver,Jong-Eun Park,Kerstin B Meyer,Bianca Dumitrascu,Sarah A Teichmann

American journal of physiology. Lung cellular and molecular physiology 326:L409-L418 PubMed38349124

2024

Defining signals that promote human alveolar type I differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Li,Y S Prakash,Qi Tan,Daniel Tschumperlin

International journal of chronic obstructive pulmonary disease 19:33-50 PubMed38197032

2024

Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-β.

Applications

Unspecified application

Species

Unspecified reactive species

Mei-Yu Lv,Ling-Ling Jin,Xi-Qiao Sang,Wen-Chao Shi,Li-Xia Qiang,Qing-Yan Lin,Shou-De Jin

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2304987 PubMed37991133

2023

Automated, High-Throughput Phenotypic Screening and Analysis Platform to Study Pre- and Post-Implantation Morphogenesis in Stem Cell-Derived Embryo-Like Structures.

Applications

Unspecified application

Species

Unspecified reactive species

Vinidhra Shankar,Clemens van Blitterswijk,Erik Vrij,Stefan Giselbrecht

iScience 26:107265 PubMed37502260

2023

FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation .

Applications

Unspecified application

Species

Unspecified reactive species

Hwee Hui Lau,Nur Shabrina Amirruddin,Larry Sai Weng Loo,Jun Wei Chan,Elhadi Iich,Vidhya Gomathi Krishnan,Shawn Hoon,Adrian Kee Keong Teo

Nature methods 20:1388-1399 PubMed37474806

2023

Efficient high-precision homology-directed repair-dependent genome editing by HDRobust.

Applications

Unspecified application

Species

Unspecified reactive species

Stephan Riesenberg,Philipp Kanis,Dominik Macak,Damian Wollny,Dorothee Düsterhöft,Johannes Kowalewski,Nelly Helmbrecht,Tomislav Maricic,Svante Pääbo
View all publications
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Product promise

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