MW 384.4 Da, Purity >99%. Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.
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- iScience 26:1072652023FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation .Applications:Unspecified applicationReactive species:Unspecified reactive speciesHwee Hui Lau,Nur Shabrina Amirruddin,Larry Sai Weng Loo,Jun Wei Chan,Elhadi Iich,Vidhya Gomathi Krishnan,Shawn Hoon,Adrian Kee Keong TeoPubMed 37502260
- Nature methods 20:1388-13992023Efficient high-precision homology-directed repair-dependent genome editing by HDRobust.Applications:Unspecified applicationReactive species:Unspecified reactive speciesStephan Riesenberg,Philipp Kanis,Dominik Macak,Damian Wollny,Dorothee Düsterhöft,Johannes Kowalewski,Nelly Helmbrecht,Tomislav Maricic,Svante PääboPubMed 37474806
- Brain : a journal of neurology 146:4766-47832023Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria O Levitin,Lettie E Rawlins,Gabriela Sanchez-Andrade,Osama A Arshad,Stephan C Collins,Stephen J Sawiak,Phillip H Iffland,Malin H L Andersson,Caleb Bupp,Emma L Cambridge,Eve L Coomber,Ian Ellis,Johanna C Herkert,Holly Ironfield,Logan Jory,Perrine F Kretz,Sarina G Kant,Alexandra Neaverson,Esther Nibbeling,Christine Rowley,Emily Relton,Mark Sanderson,Ethan M Scott,Helen Stewart,Andrew Y Shuen,John Schreiber,Liz Tuck,James Tonks,Thorkild Terkelsen,Conny van Ravenswaaij-Arts,Pradeep Vasudevan,Olivia Wenger,Michael Wright,Andrew Day,Adam Hunter,Minal Patel,Christopher J Lelliott,Peter B Crino,Binnaz Yalcin,Andrew H Crosby,Emma L Baple,Darren W Logan,Matthew E Hurles,Sebastian S GeretyPubMed 37437211
- Science advances 9:eadd50022023The temporal balance between self-renewal and differentiation of human neural stem cells requires the amyloid precursor protein.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKhadijeh Shabani,Julien Pigeon,Marwan Benaissa Touil Zariouh,Tengyuan Liu,Azadeh Saffarian,Jun Komatsu,Elise Liu,Natasha Danda,Mathilde Becmeur-Lefebvre,Ridha Limame,Delphine Bohl,Carlos Parras,Bassem A HassanPubMed 37327344
- Experimental neurology 367:1144512023Recruitment of regulatory T cells with rCCL17 promotes M2 microglia/macrophage polarization through TGFβ/TGFβR/Smad2/3 pathway in a mouse model of intracerebral hemorrhage.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuixiang Deng,Peng Jin,Shengpeng Liu,Yu He,Prativa Sherchan,John H Zhang,Ye Gong,Jiping TangPubMed 37257716
- Nature communications 14:21572023Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhixin Li,Kathy Nga-Chu Lui,Sin-Ting Lau,Frank Pui-Ling Lai,Peng Li,Patrick Ho-Yu Chung,Kenneth Kak-Yuen Wong,Paul Kwong-Hing Tam,Maria-Mercedes Garica-Barcelo,Chi-Chung Hui,Pak Chung Sham,Elly Sau-Wai NganPubMed 37061531
- Life science alliance 6:2023The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMira Brazane,Dilyana G Dimitrova,Julien Pigeon,Chiara Paolantoni,Tao Ye,Virginie Marchand,Bruno Da Silva,Elise Schaefer,Margarita T Angelova,Zornitza Stark,Martin Delatycki,Tracy Dudding-Byth,Jozef Gecz,Pierre-Yves Plaçais,Laure Teysset,Thomas Préat,Amélie Piton,Bassem A Hassan,Jean-Yves Roignant,Yuri Motorin,Clément CarréPubMed 36720500
- Frontiers in cell and developmental biology 10:10233402023Differentiation of human induced pluripotent stem cells into cortical neural stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexandra Neaverson,Malin H L Andersson,Osama A Arshad,Luke Foulser,Mary Goodwin-Trotman,Adam Hunter,Ben Newman,Minal Patel,Charlotte Roth,Tristan Thwaites,Helena Kilpinen,Matthew E Hurles,Andrew Day,Sebastian S GeretyPubMed 36684426
- Scientific reports 12:98982022Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRiffat Khanam,Arunima Sengupta,Dipankar Mukhopadhyay,Santanu ChakrabortyPubMed 35701493
- STAR protocols 3:1014472022Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSatoshi Konishi,Aleksandra Tata,Purushothama Rao TataPubMed 35712012
Key facts
- CAS number
301836-41-9
- Purity
> 99%
- Form
Solid
- Molecular weight
384.4 Da
- Molecular formula
C22H16N4O3
- PubChem identifier
4521392
- Nature
Synthetic
Target data
Alternative names
AAT 5, ACTR-IB, ACTR-IC, ACV1B_HUMAN, ACV1C_HUMAN, ACVR 1B, ACVRLK 4, ACVRLK7, ALK-4, ALK-5, ALK-7, Activin A receptor type 1B, Activin A receptor type II like kinase, Activin A receptor type II like kinase 4, Activin A receptor type II like kinase 53kDa, Activin A receptor type II like kinase, 53kD, Activin A receptor, type IC, Activin A type 1B receptor, Activin A type IB receptor, Activin receptor type 1C precursor, Activin receptor type IB, Activin receptor type IC, Activin receptor type-1B, Activin receptor type-1C, Activin receptor-like kinase 4, Activin receptor-like kinase 5, Activin receptor-like kinase 7, Acvr1c, LDS1A, LDS2A, MSSE, SKR 2, SKR 4, Serine(threonine) protein kinase receptor R2, Serine/threonine-protein kinase receptor R2, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR 1, TGFBR1 protein, TGFR1_HUMAN, TbetaR-I, Transforming growth factor beta receptor 1, Transforming growth factor beta receptor I, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD), Transforming growth factor-beta receptor type I, activin A receptor type II-like protein kinase of 53kD
Recommended products
MW 384.4 Da, Purity >99%. Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.
Alternative names
AAT 5, ACTR-IB, ACTR-IC, ACV1B_HUMAN, ACV1C_HUMAN, ACVR 1B, ACVRLK 4, ACVRLK7, ALK-4, ALK-5, ALK-7, Activin A receptor type 1B, Activin A receptor type II like kinase, Activin A receptor type II like kinase 4, Activin A receptor type II like kinase 53kDa, Activin A receptor type II like kinase, 53kD, Activin A receptor, type IC, Activin A type 1B receptor, Activin A type IB receptor, Activin receptor type 1C precursor, Activin receptor type IB, Activin receptor type IC, Activin receptor type-1B, Activin receptor type-1C, Activin receptor-like kinase 4, Activin receptor-like kinase 5, Activin receptor-like kinase 7, Acvr1c, LDS1A, LDS2A, MSSE, SKR 2, SKR 4, Serine(threonine) protein kinase receptor R2, Serine/threonine-protein kinase receptor R2, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR 1, TGFBR1 protein, TGFR1_HUMAN, TbetaR-I, Transforming growth factor beta receptor 1, Transforming growth factor beta receptor I, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD), Transforming growth factor-beta receptor type I, activin A receptor type II-like protein kinase of 53kD
Key facts
- CAS number
301836-41-9
- Purity
> 99%
- Form
Solid
- Molecular weight
384.4 Da
- Molecular formula
C22H16N4O3
- PubChem identifier
4521392
- Nature
Synthetic
- Biochemical name
4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
- Biological description
Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.
- Canonical SMILES
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
- InChI
InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
- InChIKey
FHYUGAJXYORMHI-UHFFFAOYSA-N
- IUPAC name
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
Ambient
- Appropriate long-term storage conditions
Ambient
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - SB431542, ALK inhibitor (ab120163)
2D chemical structure image of ab120163, SB431542, ALK inhibitor
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