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MW 384.4 Da, Purity >99%. Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.

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Images

Chemical Structure - SB431542 (DMSO solution), ALK inhibitor (AB146590), expandable thumbnail

Publications

Key facts

CAS number
301836-41-9
Purity
> 99%
Form
Liquid
Molecular weight
384.4 Da
Molecular formula
C22H16N4O3
PubChem identifier
4521392
Nature
Synthetic

Target data

Alternative names

AAT 5, ACTR-IB, ACTR-IC, ACV1B_HUMAN, ACV1C_HUMAN, ACVR 1B, ACVRLK 4, ACVRLK7, ALK-4, ALK-5, ALK-7, Activin A receptor type 1B, Activin A receptor type II like kinase, Activin A receptor type II like kinase 4, Activin A receptor type II like kinase 53kDa, Activin A receptor type II like kinase, 53kD, Activin A receptor, type IC, Activin A type 1B receptor, Activin A type IB receptor, Activin receptor type 1C precursor, Activin receptor type IB, Activin receptor type IC, Activin receptor type-1B, Activin receptor type-1C, Activin receptor-like kinase 4, Activin receptor-like kinase 5, Activin receptor-like kinase 7, Acvr1c, LDS1A, LDS2A, MSSE, SKR 2, SKR 4, Serine(threonine) protein kinase receptor R2, Serine/threonine-protein kinase receptor R2, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR 1, TGFBR1 protein, TGFR1_HUMAN, TbetaR-I, Transforming growth factor beta receptor 1, Transforming growth factor beta receptor I, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD), Transforming growth factor-beta receptor type I, activin A receptor type II-like protein kinase of 53kD

Recommended products

MW 384.4 Da, Purity >99%. Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.

Key facts

Purity
> 99%
PubChem identifier
4521392
Biochemical name
4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
Biological description

Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.

Canonical SMILES
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChI
InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChIKey
FHYUGAJXYORMHI-UHFFFAOYSA-N
IUPAC name
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

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1 product image

  • Chemical Structure - SB431542 (DMSO solution), ALK inhibitor (ab146590), expandable thumbnail

    Chemical Structure - SB431542 (DMSO solution), ALK inhibitor (ab146590)

    2D chemical structure image of ab146590, SB431542 (DMSO solution), ALK inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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