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AB146590

SB431542 (DMSO solution), ALK inhibitor

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(2 Publications)

SB431542 (CAS: 301836-41-9) (ab146590) is a ALK inhibitor in DMSO solution. Potent and selective inhibitor of Activin Like Kinase (ALK). Inhibits ALK 4, 5 (IC50 = 94 nM), and 7. TGF-β receptor kinase inhibitor (TRKI). MW 384.4.

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Chemical Structure - SB431542 (DMSO solution), ALK inhibitor (AB146590)
  • Chemical Structure

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Chemical Structure - SB431542 (DMSO solution), ALK inhibitor (AB146590)

2D chemical structure image of ab146590, SB431542 (DMSO solution), ALK inhibitor

Key facts

CAS number

301836-41-9

Purity

>99%

Form

Liquid

form

Molecular weight

384.4 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>1</sub><sub>6</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

4521392

Nature

Synthetic

Biochemical name

4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide

Biological description

Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.

Canonical smiles

C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

InChi

InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)

InChiKey

FHYUGAJXYORMHI-UHFFFAOYSA-N

IUPAC Name

4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

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Product details

Check out our range of ALK inhibitor biochemicals here
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 29:2702-2717.e7 PubMed31775039

2019

Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy J Kelly,Anneke Brümmer,Nima Hooshdaran,Mito Tariveranmoshabad,Jesse R Zamudio

Developmental cell 50:462-477.e5 PubMed31204172

2019

Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Mattias Malaguti,Rosa Portero Migueles,Guillaume Blin,Chia-Yi Lin,Sally Lowell
View all publications
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