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AB144415

SC-514, IKKbeta inhibitor

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(2 Publications)

MW 224.3 Da, Purity >98%. Selective, ATP-competitive, irreversible IKKβ inhibitor (IC50 = 3-12 μM). Reduces iNOS induction. Shows anti-inflammatory effects in vivo. Orally active.

View Alternative Names

I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-beta, IKK2, IKKB_HUMAN, IMD15, IkBKB, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta

Key facts

CAS number

354812-17-2

Purity

>98%

Form

Solid

form

Molecular weight

224.3 Da

Molecular formula

C<sub>9</sub>H<sub>8</sub>N<sub>2</sub>OS<sub>2</sub>

PubChem

2807869

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 100 mM

Biochemical name

3-Amino-5-(3-thiophenyl)-2-thiophenecarboxamide

Biological description

Selective, ATP-competitive, irreversible IKKβ inhibitor (IC50 = 3-12 μM). Reduces iNOS induction. Shows anti-inflammatory effects in vivo. Orally active.

Canonical smiles

C1=CSC=C1C2=CC(=C(S2)C(=O)N)N

InChi

InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12)

InChiKey

BMUACLADCKCNKZ-UHFFFAOYSA-N

IUPAC Name

3-amino-5-thiophen-3-ylthiophene-2-carboxamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 18:172 PubMed34372877

2021

Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Dayu Pan,Yongjin Li,Fuhan Yang,Zenghui Lv,Shibo Zhu,Yixin Shao,Ying Huang,Guangzhi Ning,Shiqing Feng

Molecular psychiatry : PubMed32051550

2020

A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Cursano,Chiara R Battaglia,Carolina Urrutia-Ruiz,Stefanie Grabrucker,Michael Schön,Jürgen Bockmann,Sonja Braumüller,Peter Radermacher,Francesco Roselli,Markus Huber-Lang,Tobias M Boeckers
View all publications
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