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MW 224.3 Da, Purity >98%. Selective, ATP-competitive, irreversible IKKβ inhibitor (IC50 = 3-12 μM). Reduces iNOS induction. Shows anti-inflammatory effects in vivo. Orally active.

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Publications

Key facts

CAS number
354812-17-2
Purity
> 98%
Form
Solid
Molecular weight
224.3 Da
Molecular formula
C9H8N2OS2
PubChem identifier
2807869
Nature
Synthetic

Target data

Alternative names

I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-beta, IKK2, IKKB_HUMAN, IMD15, IkBKB, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta

Recommended products

MW 224.3 Da, Purity >98%. Selective, ATP-competitive, irreversible IKKβ inhibitor (IC50 = 3-12 μM). Reduces iNOS induction. Shows anti-inflammatory effects in vivo. Orally active.

Key facts

Purity
> 98%
PubChem identifier
2807869
Solubility

Soluble in ethanol to 10 mM.

Soluble in DMSO to 100 mM.

Biochemical name
3-Amino-5-(3-thiophenyl)-2-thiophenecarboxamide
Biological description

Selective, ATP-competitive, irreversible IKKβ inhibitor (IC50 = 3-12 μM). Reduces iNOS induction. Shows anti-inflammatory effects in vivo. Orally active.

Canonical SMILES
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
InChI
InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12)
InChIKey
BMUACLADCKCNKZ-UHFFFAOYSA-N
IUPAC name
3-amino-5-thiophen-3-ylthiophene-2-carboxamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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