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AB144579

SCH-202676, GPCR allosteric modulator

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MW 348.3 Da, Purity >98%. Non-selective GPCR allosteric modulator. Inhibits adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM). Inhibits agonist and antagonist binding to GPCRs.

View Alternative Names

AHD2, AL1A1_HUMAN, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH, liver cytosolic, ALDH-E1, ALHDII, Acetaldehyde dehydrogenase 1, Aldehyde dehydrogenase, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase liver cytosolic, HEL-S-53e, MGC2318, PUMB 1, RALDH 1, Retinal dehydrogenase 1, cytosolic, epididymis luminal protein 12, epididymis luminal protein 9, epididymis secretory sperm binding protein Li 53e

1 Images
Chemical Structure - SCH-202676, GPCR allosteric modulator (AB144579)
  • Chemical Structure

Lab

Chemical Structure - SCH-202676, GPCR allosteric modulator (AB144579)

2D chemical structure image of ab144579, SCH-202676, GPCR allosteric modulator

Key facts

CAS number

265980-25-4

Purity

>98%

Form

Solid

form

Molecular weight

348.3 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>4</sub>BrN<sub>3</sub>S

PubChem

11957689

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM (with warming)

Biochemical name

SCH-202676 hydrobromide

Biological description

Non-selective GPCR allosteric modulator. Inhibits adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM). Inhibits agonist and antagonist binding to GPCRs.

Canonical smiles

CN=C1N=C(N(S1)C2=CC=CC=C2)C3=CC=CC=C3.Br

InChi

InChI=1S/C15H13N3S.BrH/c1-16-15-17-14(12-8-4-2-5-9-12)18(19-15)13-10-6-3-7-11-13;/h2-11H,1H3;1H

InChiKey

YJYGOWVFDGULLL-UHFFFAOYSA-N

IUPAC Name

N-methyl-2,3-diphenyl-1,2,4-thiadiazol-5-imine;hydrobromide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ALDH1A1 also known as aldehyde dehydrogenase 1 family member A1 is an enzyme with a molecular weight of approximately 54 kDa. It functions by catalyzing the irreversible oxidation of aldehydes to carboxylic acids which is an important step in detoxifying alcohol-derived acetaldehyde and other aldehydes. ALDH1A1 is expressed in various tissues including liver kidney and cornea. Its activity allows for maintaining cellular homeostasis by processing endogenous and exogenous aldehydes.
Biological function summary

ALDH1A1 plays significant roles in the biosynthesis of retinoic acid an important regulator of gene expression in developmental and adult processes. It does not form part of a larger enzyme complex but functions independently. The ALDH1A1 proteins contribute to the regulation of cell proliferation differentiation and survival. Researchers often measure its expression using methods like the ALDH1A1 ELISA which quantifies the protein levels in biological samples.

Pathways

The ALDH1A1 enzyme is notably implicated in the retinoid metabolism pathway and the detoxification of alcohol-derived aldehydes within the body. It is closely related to other members of the aldehyde dehydrogenase family including ALDH2 which shares similar detoxification functions. ALDH1A1’s role in retinoic acid production links it to gene expression pathways associated with cell differentiation and growth.

ALDH1A1 has associations with cancer and alcohol-induced liver disease. Its elevated expression in cancerous tissues often correlates with stem-cell like characteristics and chemoresistance. A connection exists between ALDH1A1 and ALDH2 in the context of alcohol metabolism where ALDH1A1's role in detoxifying acetaldehyde contributes to the lower risk of alcohol-induced damage. Studies explore ALDH1A1 antibodies and inhibitors as potential therapeutic approaches for these conditions.
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Product protocols

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