JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120883

Scriptaid, HDAC inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 326.35 g/mol, Purity >98%. Novel HDAC inhibitor, able to cause >100-fold increase in histone acetylation. Less toxic than trichostatin A (ab120850). Induces cell cycle arrest in vitro and in vivo. .
2 Images
Immunocytochemistry/ Immunofluorescence - Scriptaid, HDAC inhibitor (AB120883)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Scriptaid, HDAC inhibitor (AB120883)

ab10812 staining histone H3 (acetyl K9) in A549 cells treated with scriptaid (ab120883), by ICC/IF. Increase in histone H3 (acetyl K9) expression correlates with increased concentration of scriptaid, as described in literature.
The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab120883 (scriptaid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab10812 (0.1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Scriptaid, HDAC inhibitor (AB120883)
  • Chemical Structure

Lab

Chemical Structure - Scriptaid, HDAC inhibitor (AB120883)

2D chemical structure image of ab120883, Scriptaid, HDAC inhibitor

Key facts

CAS number

287383-59-9

Purity

>98%

Molecular weight

326.35 g/mol

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>8</sub>N<sub>2</sub>O<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 5 mM

Biological description

Novel HDAC inhibitor, able to cause >100-fold increase in histone acetylation. Less toxic than trichostatin A (ab120850). Induces cell cycle arrest in vitro and in vivo.

Canonical smiles

O=C(C1=CC=CC2=C1C3=CC=C2)N(CCCCCC(NO)=O)C3=O

IUPAC Name

N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB141640

BML-210, HDAC inhibitor

Chemical Structure - BML-210, HDAC inhibitor (AB141640)

  • 0
  • 0
Biochemicals

AB142060

Apicidin, HDAC inhibitor

Chemical Structure - Apicidin, HDAC inhibitor (AB142060)

  • 0
  • 0
Biochemicals

AB144480

SAHA (Vorinostat), HDAC inhibitor

  • 0
  • 0
Biochemicals

AB141262

HNHA, HDAC inhibitor

Chemical Structure - HNHA, HDAC inhibitor (AB141262)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com