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MW 306.2 Da, Purity >99%. Selective serotonin reuptake inhibitor (Ki = 2.0 μM). Shows antidepressant and antiproliferative activity. Active in vivo.

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Images

Chemical Structure - Sertraline hydrochloride, Serotonin reuptake inhibitor (AB141068), expandable thumbnail
  • Functional Studies - Sertraline hydrochloride, Serotonin reuptake inhibitor (AB141068), expandable thumbnail

Key facts

CAS number
79617-98-4
Purity
> 99%
Form
Solid
Molecular weight
306.2 Da
Molecular formula
C17H17Cl2N
PubChem identifier
54375
Nature
Synthetic

Target data

Recommended products

MW 306.2 Da, Purity >99%. Selective serotonin reuptake inhibitor (Ki = 2.0 μM). Shows antidepressant and antiproliferative activity. Active in vivo.

Key facts

Purity
> 99%
PubChem identifier
54375
Solubility

Soluble in DMSO to 100 mM.

Soluble in ethanol to 50 mM.

Biochemical name
(1R,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
Biological description

Selective serotonin reuptake inhibitor (Ki = 2.0 μM). Shows antidepressant and antiproliferative activity. Active in vivo.

Canonical SMILES
CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Isomeric SMILES
CN[C@@H]1CC[C@@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
InChI
InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m1/s1
InChIKey
VGKDLMBJGBXTGI-SJKOYZFVSA-N
IUPAC name
(1R,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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2 product images

  • Chemical Structure - Sertraline hydrochloride, Serotonin reuptake inhibitor (ab141068), expandable thumbnail

    Chemical Structure - Sertraline hydrochloride, Serotonin reuptake inhibitor (ab141068)

    2D chemical structure image of ab141068, Sertraline hydrochloride, Serotonin reuptake inhibitor

  • Functional Studies - Sertraline hydrochloride, Serotonin reuptake inhibitor (ab141068), expandable thumbnail

    Functional Studies - Sertraline hydrochloride, Serotonin reuptake inhibitor (ab141068)

    ab1223 staining transferrin in HeLa cells treated with sertraline hydrochloride (ab141068), by ICC/IF. Decrease in transferrin expression correlates with increased concentration of sertraline hydrochloride, as described in literature.
    The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab141068 (sertraline hydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab1223 (1/500 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

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