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AB141068

Sertraline hydrochloride, Serotonin reuptake inhibitor

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MW 306.2 Da, Purity >99%. Selective serotonin reuptake inhibitor (Ki = 2.0 μM). Shows antidepressant and antiproliferative activity. Active in vivo.
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Functional Studies - Sertraline hydrochloride, Serotonin reuptake inhibitor (AB141068)
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Functional Studies - Sertraline hydrochloride, Serotonin reuptake inhibitor (AB141068)

ab1223 staining transferrin in HeLa cells treated with sertraline hydrochloride (ab141068), by ICC/IF. Decrease in transferrin expression correlates with increased concentration of sertraline hydrochloride, as described in literature.
The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab141068 (sertraline hydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab1223 (1/500 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Sertraline hydrochloride, Serotonin reuptake inhibitor (AB141068)
  • Chemical Structure

Lab

Chemical Structure - Sertraline hydrochloride, Serotonin reuptake inhibitor (AB141068)

2D chemical structure image of ab141068, Sertraline hydrochloride, Serotonin reuptake inhibitor

Key facts

CAS number

79617-98-4

Purity

>99%

Form

Solid

form

Molecular weight

306.2 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>7</sub>Cl<sub>2</sub>N

PubChem

54375

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

Biochemical name

(1R,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

Biological description

Selective serotonin reuptake inhibitor (Ki = 2.0 μM). Shows antidepressant and antiproliferative activity. Active in vivo.

Canonical smiles

CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl

Isomeric smiles

CN[C@@H]1CC[C@@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl

InChi

InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m1/s1

InChiKey

VGKDLMBJGBXTGI-SJKOYZFVSA-N

IUPAC Name

(1R,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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