SF1670, PTEN inhibitor

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(5 Publications)

MW 307.3 Da, Purity >98%. Selective PTEN inhibitor (IC₅₀ = 2 μM). Elevates intracellular PIP3 signaling. Reduces neutrophil functions, including phagocytosis, oxidative burst, polarization, and chemotaxis. Active in vivo.

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1 25 dihydroxyvitamin D3 receptor, 25-dihydroxyvitamin D3 receptor, AI838772, APO1/CD95 (Fas) associated phosphatase, AW493413, B220, CATL, CATL1_HUMAN, CATS_HUMAN, CD 45, CD45 antigen, CD45R, CTSL, CTSL1, CTSS, Cathepsin L, Cathepsin L1, Cathepsin L1 light chain, Cathepsin S, Cytosolic NADP-isocitrate dehydrogenase, DKFZp686J1497, DNA polymerase iota, EC 2.7.1.6, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Eta 2, FAP 1, FLJ11090, FLJ31037, Fas associated phosphatase 1, Fas associated protein tyrosine phosphatase 1, GALK, GALK1_HUMAN, GK1, GLK1, GP180, Galactokinase, Galactokinase 1, Galactose kinase, HEL-216, HEL-S-19, HEL-S-26, HGNC:9646, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, IMD22, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, L-CA, LCK proto-oncogene, Src family tyrosine kinase, LCK_HUMAN, LSK, Lck p56, Leukocyte C-terminal Src kinase, Leukocyte common antigen, Ly-5, Lymphocyte cell-specific protein-tyrosine kinase, Lymphocyte specific protein tyrosine kinase, MEP, MGC104252, MGC112732, MGC123162, Major excreted protein, Member 1, Membrane associated protein tyrosine kinase, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NF-E2-related factor 2, NF2L2_HUMAN, NR1I1, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor subfamily 1 group I member 1, Oncogene lck, Oxalosuccinate decarboxylase, PICD, PNP 1, POLI_HUMAN, PPP1R163, PTP BAS, PTP BL, PTP E1, PTP1E, PTPL 1, PTPLE, PTPN 13, PTPRC_HUMAN, Phosphatase rip, Polymerase (DNA directed) iota, Protein YT16, Protein phosphatase 1, regulatory subunit 163, Protein tyrosine phosphatase 1 Fas associated, Protein tyrosine phosphatase PTPL1, Protein tyrosine phosphatase non receptor type 13, Protein tyrosine phosphatase, receptor type, C, Protein tyrosine phosphatase, receptor type, c polypeptide, Proto oncogene tyrosine protein kinase LCK, Proto-oncogene Lck, RAD 30B, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD3OB, RP24-311F12.2, Receptor-type tyrosine-protein phosphatase C, SCAN1, T cell-specific protein-tyrosine kinase, T lymphocyte specific protein tyrosine kinase p56lck, T200, T200 Glycoprotein, T200 leukocyte common antigen, TYDP, TYDP1_HUMAN, Tyr-DNA phosphodiesterase 1, Tyrosine protein phosphatase non receptor type 13, Tyrosine-protein kinase Lck, Tyrosyl-DNA phosphodiesterase 1, VDR_HUMAN, Vitamin D (1,25- dihydroxyvitamin D3) receptor, Vitamin D hormone receptor, Vitamin D nuclear receptor variant 1, Vitamin D receptor, Vitamin D3 receptor, YT 16, cathepsin L, 1 b, cb15, ctsl1b, epididymis secretory protein Li 19, erythroid derived 2, hPTPE1, hgg1, like 2, nuclear factor erythroid 2 like 2, p56(LSTRA) protein tyrosine kinase, p56-LCK, pp58 lck, protein tyrosine phosphatase 1E, protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase), wu:fb30g09