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AB273532

SGI1776

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MW 405.4 Da, Purity >99%. Novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3. Preliminary results from studies treating prostate cancer cells.
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Chemical Structure - SGI1776 (AB273532)
  • Chemical Structure

Lab

Chemical Structure - SGI1776 (AB273532)

Chemical structure of SGI1776, 1025065-69-3

Key facts

CAS number

1025065-69-3

Purity

>99%

Form

Solid

form

Molecular weight

405.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>2</sub>F<sub>3</sub>N<sub>5</sub>O

PubChem

24795070

Nature

Synthetic

Solubility

?40.5 mg/mL in DMSO

?101 mg/mL in EtOH

Insoluble in H2O

Biochemical name

N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine

Biological description

Novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3. Preliminary results from studies treating prostate cancer cells.

Canonical smiles

CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2

InChi

InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)

InChiKey

MHXGEROHKGDZGO-UHFFFAOYSA-N

IUPAC Name

N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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