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AB141442

SH-5, Akt inhibitor

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(3 Publications)

MW 598.7 Da, Purity >98%. Specific Akt inhibitor. Synthetic phosphatidyl inositol. Has no effect on other downstream kinases. Potent inducer of apoptosis. Cell-permeable.
1 Images
Chemical Structure - SH-5, Akt inhibitor (AB141442)
  • Chemical Structure

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Chemical Structure - SH-5, Akt inhibitor (AB141442)

2D chemical structure image of ab141442, SH-5, Akt inhibitor

Key facts

CAS number

701976-54-7

Purity

>98%

Form

Solid

form

Molecular weight

598.7 Da

Molecular formula

C<sub>2</sub><sub>9</sub>H<sub>5</sub><sub>9</sub>O<sub>1</sub><sub>0</sub>P

PubChem

16760282

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

Akt Inhibitor II

Biological description

Specific Akt inhibitor. Synthetic phosphatidyl inositol. Has no effect on other downstream kinases. Potent inducer of apoptosis. Cell-permeable.

Canonical smiles

CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OC1C(CC(C(C1O)O)O)OC)OC

Isomeric smiles

CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC1C(CC(C(C1O)O)O)OC)OC

InChi

InChI=1S/C29H59O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-37-22-24(35-2)23-38-40(33,34)39-29-26(36-3)21-25(30)27(31)28(29)32/h24-32H,4-23H2,1-3H3,(H,33,34)/t24-,25?,26?,27?,28?,29?/m1/s1

InChiKey

NRLLDDPUQZQEDV-UXPKSZKYSA-N

IUPAC Name

[(2R)-2-methoxy-3-octadecoxypropyl] (2,3,4-trihydroxy-6-methoxycyclohexyl) hydrogen phosphate

Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1818 SH-5. 1818-500 is the same size as the 500 μg size of ab141442.

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nutrients 14: PubMed36014933

2022

Astaxanthin Inhibits Matrix Metalloproteinase Expression by Suppressing PI3K/AKT/mTOR Activation in -Infected Gastric Epithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jimin Lee,Joo Weon Lim,Hyeyoung Kim

Nature materials 19:669-678 PubMed31907416

2020

Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Antonios Chronopoulos,Stephen D Thorpe,Ernesto Cortes,Dariusz Lachowski,Alistair J Rice,Vasyl V Mykuliak,Tomasz Róg,David A Lee,Vesa P Hytönen,Armando E Del Río Hernández

International journal of molecular sciences 16:28800-11 PubMed26690114

2015

Possible Mechanisms of Di(2-ethylhexyl) Phthalate-Induced MMP-2 and MMP-9 Expression in A7r5 Rat Vascular Smooth Muscle Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mei-Fen Shih,Kuang-Hung Pan,Jong Yuh Cherng
View all publications

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