JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141164

SHU9119, Melanocortin 3 and 4 (MC3 and MC4) receptor antagonist

Be the first to review this product! Submit a review

|

(3 Publications)

MW 1074.25 g/mol, Purity >95%. Potent melanocortin 3 and 4 (MC3 and MC4) receptor antagonist (IC50 values are 0.23 and 0.06 nM, respectively). Also shows MC5 partial agonist activity (EC50 = 0.12 nM). Dose-dependently increases food intake following central administration.
1 Images
Chemical Structure - SHU9119, Melanocortin 3 and 4 (MC3 and MC4) receptor antagonist (AB141164)
  • Chemical Structure

Lab

Chemical Structure - SHU9119, Melanocortin 3 and 4 (MC3 and MC4) receptor antagonist (AB141164)

2D chemical structure image of ab141164, SHU9119, Melanocortin 3 and 4 (MC3 and MC4) receptor antagonist

Key facts

CAS number

168482-23-3

Purity

>95%

Form

Solid

form

Molecular weight

1074.25 g/mol

Nature

Synthetic

Solubility

Soluble in water

Biological description

Potent melanocortin 3 and 4 (MC3 and MC4) receptor antagonist (IC50 values are 0.23 and 0.06 nM, respectively). Also shows MC5 partial agonist activity (EC50 = 0.12 nM). Dose-dependently increases food intake following central administration.

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 10:17734 PubMed33082383

2020

Neuroprotective effect of ACTH on collagenase-induced peri-intraventricular hemorrhage in newborn male rats.

Applications

Unspecified application

Species

Unspecified reactive species

Camila A Martins,Laura Tartari Neves,Marina M B P de Oliveira,Pamela Brambilla Bagatini,Rafaela Barboza,Régis Gemerasca Mestriner,Léder Leal Xavier,Alberto A Rasia-Filho

Cell reports 33:108267 PubMed33053350

2020

MCR Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression.

Applications

Unspecified application

Species

Unspecified reactive species

Giuseppe Bruschetta,Sungho Jin,Zhong-Wu Liu,Jung Dae Kim,Sabrina Diano

Nature communications 7:10782 PubMed26923837

2016

Hypothalamic leptin action is mediated by histone deacetylase 5.

Applications

Unspecified application

Species

Unspecified reactive species

Dhiraj G Kabra,Katrin Pfuhlmann,Cristina García-Cáceres,Sonja C Schriever,Veronica Casquero García,Adam Fiseha Kebede,Esther Fuente-Martin,Chitrang Trivedi,Kristy Heppner,N Henriette Uhlenhaut,Beata Legutko,Uma D Kabra,Yuanqing Gao,Chun-Xia Yi,Carmelo Quarta,Christoffer Clemmensen,Brian Finan,Timo D Müller,Carola W Meyer,Marcelo Paez-Pereda,Kerstin Stemmer,Stephen C Woods,Diego Perez-Tilve,Robert Schneider,Eric N Olson,Matthias H Tschöp,Paul T Pfluger
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB120189

alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist

Functional Studies - alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist (AB120189)

  • 0
  • 0
Biochemicals

AB120440

NECA, adenosine agonist

Chemical Structure - NECA, adenosine agonist (AB120440)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Biochemicals

AB144783

N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin

Chemical Structure - N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin (AB144783)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com