MW 418.6 Da, Purity >99%. HMG-CoA reductase inhibitor. Hypolipidemic, decreasing low denisty lipoprotein (LDL) levels. Implicated in a multitude of biological functions, demonstrating anticancer and anti-inflammatory properties.
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- Toxicological sciences : an official journal of the Society of Toxicology 185:232-2452021Binge Ethanol Exposure in Mice Represses Expression of Genes Involved in Osteoblast Function and Induces Expression of Genes Involved in Osteoclast Differentiation Independently of Endogenous Catalase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexandra Denys,Kim B Pedersen,James Watt,Allison R Norman,Michelle L Osborn,Jin-Ran Chen,Cole Maimone,Shana Littleton,Vasilis Vasiliou,Martin J J RonisPubMed 34755883
- Bioactive materials 6:2511-25222021Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBingyang Dai,Xu Li,Jiankun Xu,Yuwei Zhu,Le Huang,Wenxue Tong,Hao Yao,Dick Ho-Kiu Chow,Ling QinPubMed 33665494
- Drug design, development and therapy 11:3273-32802017Differences of statin activity in 2D and 3D pancreatic cancer cell cultures.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMiglė Paškevičiūtė et. al.PubMed 29180851
- Journal of Cancer 8:1655-16642017Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYikun Peng et. al.PubMed 28775785
- Proceedings of the National Academy of Sciences of 113:11525-115302016Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKuei-Chun Wang et. al.PubMed 27671657
Key facts
- CAS number
- 79902-63-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 418.6 Da
- Molecular formula
- C25H38O5
- PubChem identifier
- 54454
- Nature
- Synthetic
Target data
Alternative names
3 hydroxy 3 methylglutaryl CoA reductase, 3 hydroxymethylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3H3M, HMDH_HUMAN, HMG CoAR, HMG-CoA reductase, Hydroxymethylglutaryl CoA reductase, LDLCQ3, MGC103269
Recommended products
MW 418.6 Da, Purity >99%. HMG-CoA reductase inhibitor. Hypolipidemic, decreasing low denisty lipoprotein (LDL) levels. Implicated in a multitude of biological functions, demonstrating anticancer and anti-inflammatory properties.
Key facts
- CAS number
- 79902-63-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 418.6 Da
- Molecular formula
- C25H38O5
- PubChem identifier
- 54454
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- Simvastatin
- Biological description
HMG-CoA reductase inhibitor. Hypolipidemic, decreasing low denisty lipoprotein (LDL) levels. Implicated in a multitude of biological functions, demonstrating anticancer and anti-inflammatory properties.
- Canonical SMILES
- CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
- Isomeric SMILES
- CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
- InChI
- InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
- InChIKey
- RYMZZMVNJRMUDD-HGQWONQESA-N
- IUPAC name
- [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - Simvastatin, HMG-CoA reductase inhibitor (ab120505)
2D chemical structure image of ab120505, Simvastatin, HMG-CoA reductase inhibitor
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