MW 413.1 Da, Purity >99%. Potent, selective D1 receptor antagonist (Ki = 0.4 nM). Centrally active following systemic administration. Various neurological effects in vitro and in vivo.
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Key facts
- CAS number
- 108179-91-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 413.1 Da
- Molecular formula
- C17H19Br2NO
- PubChem identifier
- 23581817
- Nature
- Synthetic
Associated Products
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1 product for Alternative Version
Alternative names
ERK-2, ERT1, Extracellular signal-regulated kinase 2, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MK01_HUMAN, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, P38, P41, PRKM 2, PRKM1, p42-MAPK, protein kinase, mitogen-activated, 1, protein kinase, mitogen-activated, 2, protein tyrosine kinase ERK2
Recommended products
MW 413.1 Da, Purity >99%. Potent, selective D1 receptor antagonist (Ki = 0.4 nM). Centrally active following systemic administration. Various neurological effects in vitro and in vivo.
Key facts
- CAS number
- 108179-91-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 413.1 Da
- Molecular formula
- C17H19Br2NO
- PubChem identifier
- 23581817
- Nature
- Synthetic
- Solubility
Soluble in water to 5 mM, in ethanol to 25 mM and in DMSO to 100 mM.
- Biochemical name
- SKF 83566 hydrobromide
- Biological description
Potent, selective D1 receptor antagonist (Ki = 0.4 nM). Centrally active following systemic administration. Various neurological effects in vitro and in vivo.
- Canonical SMILES
- CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Br.Br
- InChI
- InChI=1S/C17H18BrNO.BrH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H
- InChIKey
- SDQJYYGODYRPBR-UHFFFAOYSA-N
- IUPAC name
- 8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrobromide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ERK2 also known as Extracellular signal-Regulated Kinase 2 is a serine/threonine protein kinase in the mitogen-activated protein kinase (MAPK) family with a mass of approximately 42 kDa. This kinase is expressed in many cell types and tissues including the brain liver and lungs. ERK2 plays a significant role in cellular processes such as proliferation differentiation and survival. It is often analyzed using specific assays including ERK2 ELISA and examination of cell lysate samples to determine expression levels and activity.
- Biological function summary
ERK2 influences several key cellular functions. It functions as part of a signaling cascade transmitting signals from the exterior to the cell nucleus. In this cascade ERK2 is often part of a multi-protein complex that undergoes sequential phosphorylation. Through these mechanisms ERK2 regulates gene expression and is a pivotal component of the MAPK/ERK pathway ensuring the proper response to growth signals and stress stimuli.
- Pathways
ERK2 is a central component of the MAPK/ERK signaling pathway and the PI3K/AKT pathway. These pathways play critical roles in cell cycle regulation and apoptosis. ERK2 activation leads to its interaction with the MEK1/2 proteins which further allows the transmission of mitogenic signals. The interplay between ERK2 and related proteins like E460 often impacts cellular growth and development as it precisely controls the phosphorylation events within the pathway.
- Associated diseases and disorders
ERK2 is connected to certain types of cancer and neurodegenerative diseases. Aberrations in ERK2 signaling pathways are often linked to tumorigenesis where altered interaction with proteins such as Raf and MEK1/2 disrupts cell cycle regulation and apoptosis. In neurodegenerative disorders dysregulated ERK2 activity has been associated with proteins contributing to Alzheimer’s disease indicating its involvement in neuronal survival and stress response mechanisms.
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1 product image
Chemical Structure - SKF 83566 hydrobromide, D1 receptor antagonist (ab141146)
2D chemical structure image of ab141146, SKF 83566 hydrobromide, D1 receptor antagonist
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