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AB120280

SKF 96365, TRP channel blocker

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(17 Publications)

MW 402.9 Da, Purity >99%. Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry. Achieve your results faster with highly validated, pure and trusted compounds.
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Functional Studies - SKF 96365, TRP channel blocker (AB120280)
  • FuncS

PubMed

Functional Studies - SKF 96365, TRP channel blocker (AB120280)

TRP channel blockers affect most of the L-arginine-induced responses.

L-arginine-induced Ca2+ responses of two ORNs of another individual slice of the lateral MOE (cyan and red trace). Incubation with SKF-96365 (80 μM; 10 min; lilac-shaded panel) led to a strong reduction of the Ca2+ transient in only one of the two ORNs (red trace). The response of the affected ORN recovered after 10 min of washout (right-hand traces). ORNs unaffected and affected by SKF-96365, expressed as percentage of total ORNs tested (histogram; 25 cells, 4 slices).

(From Figure 5C of Sansone et al).

Sansone et al PLoS One. 2014; 9(1): e87721. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - SKF 96365, TRP channel blocker (AB120280)
  • Chemical Structure

Lab

Chemical Structure - SKF 96365, TRP channel blocker (AB120280)

2D chemical structure image of ab120280, SKF 96365, TRP channel blocker

Key facts

CAS number

130495-35-1

Purity

>99%

Form

Solid

form

Molecular weight

402.9 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>7</sub>ClN<sub>2</sub>O<sub>3</sub>

PubChem

104955

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

1-(2-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole hydrochloride

Biological description

Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.

Canonical smiles

COC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl

InChi

InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H

InChiKey

FWLPKVQUECFKSW-UHFFFAOYSA-N

IUPAC Name

1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (17)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 82:238 PubMed40515767

2025

Resting Ca fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Caroline Fecher,Annemarie Sodmann,Felicitas Schlott,Juliane Jaepel,Franziska Schmitt,Isabella Lengfelder,Thorsten Bischler,Bernhard Nieswandt,Konstanze F Winklhofer,Robert Blum

iScience 24:103339 PubMed34816101

2021

Resolving macrophage polarization through distinct Ca entry channel that maintains intracellular signaling and mitochondrial bioenergetics.

Applications

Unspecified application

Species

Unspecified reactive species

Viviane Nascimento Da Conceicao,Yuyang Sun,Karthik Ramachandran,Arun Chauhan,Amritha Raveendran,Manigandan Venkatesan,Bony DeKumar,Soumya Maity,Neelanjan Vishnu,George A Kotsakis,Paul F Worley,Donald L Gill,Bibhuti B Mishra,Muniswamy Madesh,Brij B Singh

Frontiers in cell and developmental biology 8:594283 PubMed33604333

2021

TRPC6 Attenuates Cortical Astrocytic Apoptosis and Inflammation in Cerebral Ischemic/Reperfusion Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Liu,Manli Chen,Kun Lin,Xuwu Xiang,Jing Yang,Yueying Zheng,Xiaoxing Xiong,Shengmei Zhu

Cell research 31:758-772 PubMed33469157

2021

Direct control of store-operated calcium channels by ultrafast laser.

Applications

Unspecified application

Species

Unspecified reactive species

Pan Cheng,Xiaoying Tian,Wanyi Tang,Juan Cheng,Jin Bao,Haipeng Wang,Sisi Zheng,Youjun Wang,Xunbin Wei,Tunan Chen,Hua Feng,Tian Xue,Keisuke Goda,Hao He

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 44:971-981 PubMed30504797

2018

VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Jiang,Wei-Jye Lin,Benoit Labonté,Carol A Tamminga,Gustavo Turecki,Eric J Nestler,Scott J Russo,Stephen R Salton

Molecular medicine reports 17:898-910 PubMed29115500

2017

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Chen,Dongming Zheng,Hong Cui,Sishi Liu,Lijuan Zhang,Caixia Liu

Scientific reports 7:14512 PubMed29109429

2017

Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum.

Applications

Unspecified application

Species

Unspecified reactive species

Kinga Gazda,Jacek Kuznicki,Tomasz Wegierski

Cell death & disease 8:e2938 PubMed28726786

2017

Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Min Zhu,Hongyi Wang,Jiantao Cui,Wenmei Li,Guo An,Yuanming Pan,Qingying Zhang,Rui Xing,Youyong Lu

Frontiers in cellular neuroscience 11:182 PubMed28713246

2017

Differential Contribution of Ca-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Eric C Lin,Crescent L Combe,Sonia Gasparini

Scientific reports 7:3039 PubMed28596571

2017

The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Guo,Yongyuan Ma,Shanbo Ma,Fei Mu,Jiao Deng,Jialin Duan,Lize Xiong,Ying Yin,Yanhua Wang,Miaomaio Xi,Aidong Wen
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