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AB120740

(±)-SKF38393 hydrochloride, D1-like dopamine receptor agonist

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(1 Publication)

MW 291.77 Da, Purity >98%. D1-like dopamine receptor agonist. pKi values are 9 (D1), 6.8 (D2), 5.3 (D3), 6.0 (D4) and 9.3 (D5). Ki values are 151 and 2364 nM for D1-like and D2-like dopamine receptors, respectively. Centrally active upon systemic administration.
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Chemical Structure - (±)-SKF38393 hydrochloride, D1-like dopamine receptor agonist (AB120740)
  • Chemical Structure

Lab

Chemical Structure - (±)-SKF38393 hydrochloride, D1-like dopamine receptor agonist (AB120740)

2D chemical structure image of ab120740, SKF38393 hydrochloride, D1-like dopamine receptor agonist

Key facts

CAS number

62717-42-4

Purity

>98%

Form

Solid

form

Molecular weight

291.77 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>8</sub>ClNO<sub>2</sub>

PubChem

147514

Nature

Synthetic

Solubility

Soluble in water to 25 mM

Soluble in DMSO to 100 mM

Biochemical name

1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride

Biological description

D1-like dopamine receptor agonist. pKi values are 9 (D1), 6.8 (D2), 5.3 (D3), 6.0 (D4) and 9.3 (D5). Ki values are 151 and 2364 nM for D1-like and D2-like dopamine receptors, respectively. Centrally active upon systemic administration.

Canonical smiles

C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl

InChi

InChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H

InChiKey

YEWHJCLOUYPAOH-UHFFFAOYSA-N

IUPAC Name

5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 6:23527 PubMed26997328

2016

Inhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng-long Xie,Jing-Ya Lin,Mei-Hua Wang,Yu Zhang,Su-fang Zhang,Xi-Jin Wang,Zhen-Guo Liu
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