MW 410.5 Da, Purity >90%. Specific non-lipid sphingosine kinase (SK) inhibitor. Inhibits SK1 and SK2. Inhibits sphingosine 1-phosphate (S1P) production and pro-apoptotic. Induces autophagy. Cell permeable and active in vivo and in vitro.
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- International journal of molecular sciences 20:2019Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRyo Terao et. al.PubMed 31357484
- Oncotarget 7:71873-718862016Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarguerite Mrad,Caroline Imbert,Virginie Garcia,Florian Rambow,Nicole Therville,Stéphane Carpentier,Bruno Ségui,Thierry Levade,Rania Azar,Jean-Christophe Marine,Mona Diab-Assaf,Céline Colacios,Nathalie Andrieu-AbadiePubMed 27708249
- Nature communications 6:85652015Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSusannah H Kassmer et. al.PubMed 26456232
Key facts
- CAS number
- 306301-68-8
- Purity
- > 90%
- Form
- Solid
- Molecular weight
- 410.5 Da
- Molecular formula
- C25H22N4O2
- PubChem identifier
- 137269090
- Nature
- Synthetic
Recommended products
MW 410.5 Da, Purity >90%. Specific non-lipid sphingosine kinase (SK) inhibitor. Inhibits SK1 and SK2. Inhibits sphingosine 1-phosphate (S1P) production and pro-apoptotic. Induces autophagy. Cell permeable and active in vivo and in vitro.
Key facts
- CAS number
- 306301-68-8
- Purity
- > 90%
- Form
- Solid
- Molecular weight
- 410.5 Da
- Molecular formula
- C25H22N4O2
- PubChem identifier
- 137269090
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- SKI-I, Sphingosine Kinase Inhibitor
- Biological description
Specific non-lipid sphingosine kinase (SK) inhibitor. Inhibits SK1 and SK2. Inhibits sphingosine 1-phosphate (S1P) production and pro-apoptotic. Induces autophagy. Cell permeable and active in vivo and in vitro.
- Canonical SMILES
- C1C(NNC1C(=O)NN=CC2=C(C=CC3=CC=CC=C32)O)C4=CC5=CC=CC=C5C=C4
- Isomeric SMILES
- C1C(NNC1C(=O)N/N=C/C2=C(C=CC3=CC=CC=C32)O)C4=CC5=CC=CC=C5C=C4
- InChI
- InChI=1S/C25H22N4O2/c30-24-12-11-17-6-3-4-8-20(17)21(24)15-26-29-25(31)23-14-22(27-28-23)19-10-9-16-5-1-2-7-18(16)13-19/h1-13,15,22-23,27-28,30H,14H2,(H,29,31)/b26-15+
- InChIKey
- LMCALHGHWCFFHD-CVKSISIWSA-N
- IUPAC name
- N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-5-naphthalen-2-ylpyrazolidine-3-carboxamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - SKI-I, Sphingosine Kinase Inhibitor (ab142209)
2D chemical structure image of ab142209, SKI-I, Sphingosine Kinase Inhibitor
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