SM 7368, NF-kappaB inhibitor

Key facts

CAS number

380623-76-7

Purity

>99%

Form

Solid

form

Molecular weight

328.69 Da

Molecular formula

C₁₀H₅ClN₄O₅S

PubChem

11537217

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide

Biological description

Selective NF-κB inhibitor. Inhibits TNF-α induced MMP-9 expression. Decreases MMP-9 expression in AMPKα knockout cells. Putative antimetastatic agent.

Canonical smiles

C1=CC(=C(C=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-])Cl)[N+](=O)[O-]

InChi

InChI=1S/C10H5ClN4O5S/c11-6-3-5(1-2-7(6)14(17)18)9(16)13-10-12-4-8(21-10)15(19)20/h1-4H,(H,12,13,16)

InChiKey

XCHLNGBTHLJLFG-UHFFFAOYSA-N

IUPAC Name

3-chloro-4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide