SM21 maleate, sigma2 receptor antagonist

Key facts

CAS number

155059-42-0

Purity

>99%

Form

Solid

form

Molecular weight

453.92 g/mol

Nature

Synthetic

Solubility

Soluble in water to 25 mM

Biological description

Potent, selective σ₂ receptor antagonist. Increases acetylcholine at central muscarinic synapses. Shows potent analgesic and nootropic effects in vivo.

Isomeric smiles

CN3[C@H]1CC[C@@H]3C[C@@H](C1)OC(=O)C(CC)OC2CCC(CL)CC2.O=C(O)/C=C\C(=O)O

InChi

InChI=1S/C18H24ClNO3.C4H4O4/c1-3-17(22-15-8-4-12(19)5-9-15)18(21)23-16-10-13-6-7-14(11-16)20(13)2;5-3(6)1-2-4(7)8/h4-5,8-9,13-14,16-17H,3,6-7,10-11H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t13-,14+,16+,17?;

InChiKey

BHXGTFUQDGMXHA-PMVATAOKSA-N

IUPAC Name

2-(4-Chlorophenoxy)butanoic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester maleate