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MW 224.17 Da, Purity >98%. Cell permeable, selective SCFMet30 ubiquitin E3 ligase inhibitor. Enhances the action of rapamycin. Induces cell cycles arrest (IC50 = 10-30 μM). Active *in vivo.*.

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Images

Chemical Structure - SMER3, SCFMet30 ubiquitin E3 ligase inhibitor (AB144596), expandable thumbnail

Key facts

CAS number
67200-34-4
Purity
> 98%
Form
Solid
Molecular weight
224.17 Da
Molecular formula
C11H4N4O2
PubChem identifier
568763
Nature
Synthetic

Target data

Recommended products

MW 224.17 Da, Purity >98%. Cell permeable, selective SCFMet30 ubiquitin E3 ligase inhibitor. Enhances the action of rapamycin. Induces cell cycles arrest (IC50 = 10-30 μM). Active *in vivo.*.

Key facts

Purity
> 98%
PubChem identifier
568763
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-E]pyrazin-9-one
Biological description

Cell permeable, selective SCFMet30 ubiquitin E3 ligase inhibitor. Enhances the action of rapamycin. Induces cell cycles arrest (IC50 = 10-30 μM). Active *in vivo.*

Canonical SMILES
C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
InChI
InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
InChIKey
SFSSAKVWCKFRHE-UHFFFAOYSA-N
IUPAC name
13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - SMER3, SCFMet30 ubiquitin E3 ligase inhibitor (ab144596), expandable thumbnail

    Chemical Structure - SMER3, SCFMet30 ubiquitin E3 ligase inhibitor (ab144596)

    2D chemical structure image of ab144596, SMER3, SCFMet30 ubiquitin E3 ligase inhibitor

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Product protocols

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