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AB144596

SMER3, SCFMet30 ubiquitin E3 ligase inhibitor

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MW 224.17 Da, Purity >98%. Cell permeable, selective SCFMet30 ubiquitin E3 ligase inhibitor. Enhances the action of rapamycin. Induces cell cycles arrest (IC50 = 10-30 μM). Active *in vivo.*.
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Chemical Structure - SMER3, SCFMet30 ubiquitin E3 ligase inhibitor (AB144596)
  • Chemical Structure

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Chemical Structure - SMER3, SCFMet30 ubiquitin E3 ligase inhibitor (AB144596)

2D chemical structure image of ab144596, SMER3, SCFMet30 ubiquitin E3 ligase inhibitor

Key facts

CAS number

67200-34-4

Purity

>98%

Form

Solid

form

Molecular weight

224.17 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>4</sub>N<sub>4</sub>O<sub>2</sub>

PubChem

568763

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-E]pyrazin-9-one

Biological description

Cell permeable, selective SCFMet30 ubiquitin E3 ligase inhibitor. Enhances the action of rapamycin. Induces cell cycles arrest (IC50 = 10-30 μM). Active *in vivo.*

Canonical smiles

C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O

InChi

InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

InChiKey

SFSSAKVWCKFRHE-UHFFFAOYSA-N

IUPAC Name

13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Primary Antibodies

AB64677

Anti-SCF antibody

BOND RX™ Validated

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Biochemicals

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Biochemicals

AB287060

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