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AB120014

SNAP, NO donor

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(8 Publications)

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) (ab120014) is a nitric oxide NO donor and acts as a vasodilator in vitro and in vivo, that does not induce pharmacological tolerance. MW 220.25.

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Chemical Structure - SNAP, NO donor (AB120014)
  • Chemical Structure

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Chemical Structure - SNAP, NO donor (AB120014)

2D chemical structure image of ab120014, SNAP, NO donor

Key facts

CAS number

67776-06-1

Form

Solid

form

Molecular weight

220.25 Da

Molecular formula

C<sub>7</sub>H<sub>1</sub><sub>2</sub>N<sub>2</sub>O<sub>4</sub>S

PubChem

5231

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

S-Nitroso-N-acetyl-DL-penicillamine

Biological description

NO donor. Vasodilator in vitro and in vivo, that does not induce pharmacological tolerance.

Canonical smiles

CC(=O)NC(C(=O)O)C(C)(C)SN=O

InChi

InChI=1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)

InChiKey

ZIIQCSMRQKCOCT-UHFFFAOYSA-N

IUPAC Name

2-acetamido-3-methyl-3-nitrososulfanylbutanoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of vascular research 61:179-196 PubMed38952123

2024

Nitric Oxide/Glucose Transporter Type 4 Pathway Mediates Cardioprotection against Ischemia/Reperfusion Injury under Hyperglycemic and Diabetic Conditions in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Aisha Al-Kouh,Fawzi Babiker

ACS applied bio materials 3:6779-6789 PubMed33644704

2020

Analysis of vascular inflammation against bioresorbable Zn-Ag based alloys.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander A Oliver,Roger J Guillory,Katie L Flom,Lea M Morath,Timothy M Kolesar,Ehsan Mostaed,Malgorzata Sikora-Jasinska,Jaroslaw W Drelich,Jeremy Goldman

The Journal of biological chemistry 290:30616-23 PubMed26507659

2015

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Hua Zhou,Alexis Bavencoffe,Hui-Lin Pan

The Journal of biological chemistry 289:16421-9 PubMed24719320

2014

Inhibition of the cardiac Na⁺ channel Nav1.5 by carbon monoxide.

Applications

Unspecified application

Species

Unspecified reactive species

Jacobo Elies,Mark L Dallas,John P Boyle,Jason L Scragg,Adrian Duke,Derek S Steele,Chris Peers

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:15675-85 PubMed24089475

2013

Non-Hebbian long-term potentiation of inhibitory synapses in the thalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Rahel Sieber,Rogier Min,Thomas Nevian

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:17383-91 PubMed22131400

2011

Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Henning Fenselau,Bernhard Heinke,Jürgen Sandkühler

The Journal of biological chemistry 286:33190-202 PubMed21813646

2011

Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Gao Jin,Shao-Rui Chen,Xue-Hong Cao,Li Li,Hui-Lin Pan

The Journal of physiology 586:5091-9 PubMed18772202

2008

Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Damian P Bright,Stephen G Brickley
View all publications
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