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MW 110.09 Da. Histone deacetylase inhibitor (IC50 values are 0.3, 0.4 and 0.3 mM for HDAC1, 2 and 7, respectively). Shows no inhibition of HDAC6 and 10. Anticancer activity. Crosses the blood-brain barrier.

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Images

Chemical Structure - Sodium butyrate, Histone deacetylase inhibitor (AB120948), expandable thumbnail
  • Western blot - Sodium butyrate, Histone deacetylase inhibitor (AB120948), expandable thumbnail

Publications

Key facts

CAS number
156-54-7
Form
Solid
Molecular weight
110.09 Da
Molecular formula
C4H7NaO2
PubChem identifier
5222465
Nature
Synthetic

Target data

Alternative names

FFA3R, FFAR3_HUMAN, Free fatty acid receptor 3, G-protein coupled receptor 41, GPR41, gpcr41, gpr42

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MW 110.09 Da. Histone deacetylase inhibitor (IC50 values are 0.3, 0.4 and 0.3 mM for HDAC1, 2 and 7, respectively). Shows no inhibition of HDAC6 and 10. Anticancer activity. Crosses the blood-brain barrier.

Key facts

PubChem identifier
5222465
Solubility

Soluble in water to 100 mM.

Biochemical name
Sodium butyrate
Biological description

Histone deacetylase inhibitor (IC50 values are 0.3, 0.4 and 0.3 mM for HDAC1, 2 and 7, respectively). Shows no inhibition of HDAC6 and 10. Anticancer activity. Crosses the blood-brain barrier.

Canonical SMILES
CCCC(=O)[O-].[Na+]
InChI
InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChIKey
MFBOGIVSZKQAPD-UHFFFAOYSA-M
IUPAC name
sodium;butanoate

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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2 product images

  • Chemical Structure - Sodium butyrate, Histone deacetylase inhibitor (ab120948), expandable thumbnail

    Chemical Structure - Sodium butyrate, Histone deacetylase inhibitor (ab120948)

    2D chemical structure image of ab120948, Sodium butyrate, Histone deacetylase inhibitor

  • Western blot - Sodium butyrate, Histone deacetylase inhibitor (ab120948), expandable thumbnail

    Western blot - Sodium butyrate, Histone deacetylase inhibitor (ab120948)

    HeLa cells were incubated at 37°C for 6h with vehicle control (0 μM) and different concentrations of sodium butyrate (ab120948). Increased expression of histone H3 (acetyl K27) (Anti-Histone H3 (acetyl K27) antibody - ChIP Grade ab4729) in HeLa cells correlates with an increase sodium butyrate concentration, as described in literature.

    Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with Anti-Histone H3 (acetyl K27) antibody - ChIP Grade ab4729 at 1 μg/ml and Anti-beta Actin antibody - Loading Control ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.

    HeLa cells were incubated at 37°C for 6h with vehicle control (0 μM) and different concentrations of sodium butyrate (ab120948). Increased expres

    All lanes: Western blot - Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (Anti-Histone H3 (acetyl K27) antibody - ChIP Grade ab4729)

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 15 kDa

    Observed band size: 17 kDa

    Exposure time: 10s

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