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AB145643

Sodium oxamate, Weak lactate dehydrogenase inhibitor

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(2 Publications)

MW 111.03 Da, Purity >99%. Weak lactate dehydrogenase inhibitor (IC50 values are 600 and 4400 μM in H460 and A549 cells respectively). Inhibits glycolysis and gluconeogenesis. Pyruvate (ab145036) analog. Decreases extracellular acidification rate.
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Chemical Structure - Sodium oxamate, Weak lactate dehydrogenase inhibitor (AB145643)
  • Chemical Structure

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Chemical Structure - Sodium oxamate, Weak lactate dehydrogenase inhibitor (AB145643)

2D chemical structure image of ab145643, Sodium oxamate, Weak lactate dehydrogenase inhibitor

Key facts

CAS number

565-73-1

Purity

>99%

Form

Solid

form

Molecular weight

111.03 Da

Molecular formula

C<sub>2</sub>H<sub>2</sub>NNaO<sub>3</sub>

PubChem

5242

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Sodium oxamate

Biological description

Weak lactate dehydrogenase inhibitor (IC50 values are 600 and 4400 μM in H460 and A549 cells respectively). Inhibits glycolysis and gluconeogenesis. Pyruvate (ab145036) analog. Decreases extracellular acidification rate.

Canonical smiles

C(=O)(C(=O)[O-])N.[Na+]

InChi

InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1

InChiKey

RQVZIJIQDCGIKI-UHFFFAOYSA-M

IUPAC Name

sodium;oxamate

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Biochemicals

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D-AP5, NMDA glutamate site antagonist

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Biochemicals

AB142442

Lonidamine, Hexokinase inhibitor

Chemical Structure - Lonidamine, Hexokinase inhibitor (AB142442)

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Biochemicals

AB142242

2-Deoxy-D-glucose, glucose analog

Chemical Structure - 2-Deoxy-D-glucose, glucose analog (AB142242)

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Biochemicals

AB144667

YZ9, PFKFB3 inhibitor

Chemical Structure - YZ9, PFKFB3 inhibitor (AB144667)

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2580 Sodium Oxamate. 2580-5g is the same size as the 5 g size of ab145643.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 79:103479 PubMed39742570

2025

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Kaifeng Niu,Zixiang Chen,Mengge Li,Guannan Ma,Yuchun Deng,Ji Zhang,Di Wei,Jiaqi Wang,Yongliang Zhao

Annals of clinical and translational neurology 10:1873-1884 PubMed37632130

2023

Glycolytic lactate production supports status epilepticus in experimental animals.

Applications

Unspecified application

Species

Unspecified reactive species

Daria Skwarzynska,Huayu Sun,Izabela Kasprzak,Supriya Sharma,John Williamson,Jaideep Kapur
View all publications
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