MW 160.1 g/mol, Purity >99%. Cell-permeable anti-inflammatory agent. Inhibits cyclooxygenases preventing prostaglandin formation. Inhibits components of the MAPK cascade, NF-κB and AP-1. Induces apoptosis through p38 MAPK activation.
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- Biochemical pharmacology 154:318-3342018Celecoxib inhibits mitochondrial O consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRhys Pritchard et. al.PubMed 29800556
- European journal of pharmacology 447:1-92002Anti-inflammatory effects of aspirin and sodium salicylate.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRainer Amann,Bernhard A PeskarPubMed 12106797
- Molecular and cellular biology 18:78-841998Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesP Schwenger,D Alpert,E Y Skolnik,J VilcekPubMed 9418855
- Molecular pharmacology 51:907-121997Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJ A Mitchell,M Saunders,P J Barnes,R Newton,M G BelvisiPubMed 9187256
- The Journal of biological chemistry 271:8089-941996Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate.Applications:Unspecified applicationReactive species:Unspecified reactive speciesP Schwenger,E Y Skolnik,J VilcekPubMed 8626494
Key facts
- CAS number
54-21-7
- Purity
> 99%
- Form
Solid
- Molecular weight
160.1 g/mol
- Molecular formula
C7H5NaO3
- Nature
Synthetic
Recommended products
MW 160.1 g/mol, Purity >99%. Cell-permeable anti-inflammatory agent. Inhibits cyclooxygenases preventing prostaglandin formation. Inhibits components of the MAPK cascade, NF-κB and AP-1. Induces apoptosis through p38 MAPK activation.
Key facts
- CAS number
54-21-7
- Purity
> 99%
- Form
Solid
- Molecular weight
160.1 g/mol
- Molecular formula
C7H5NaO3
- Nature
Synthetic
- Solubility
Soluble in water to 100 mM.
- Biological description
Cell-permeable anti-inflammatory agent. Inhibits cyclooxygenases preventing prostaglandin formation. Inhibits components of the MAPK cascade, NF-κB and AP-1. Induces apoptosis through p38 MAPK activation.
- IUPAC name
2-Hydroxybenzoic acid sodium salt
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
Ambient
- Appropriate long-term storage conditions
Ambient
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Sodium salicylate, anti-inflammatory agent (ab120746)
2D chemical structure image of ab120746, Sodium salicylate, anti-inflammatory agent
Functional Studies - Sodium salicylate, anti-inflammatory agent (ab120746)
THP1 cells were incubated at 37°C for 40h with vehicle control (0 μM) and different concentrations of sodium salicylate (ab120746). Decreased expression of scavenging receptor SR-BI (Anti-Scavenging Receptor SR-BI antibody [EP1556Y] ab52629) in THP1 cells correlates with an increase in sodium salicylate concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with Anti-Scavenging Receptor SR-BI antibody [EP1556Y] ab52629 at 1/2000 dilution and Anti-beta Actin antibody ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.
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