Sodium salicylate, anti-inflammatory agent
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(1 Publication)
- FuncS
Unknown
Functional Studies - Sodium salicylate, anti-inflammatory agent (AB120746)
THP1 cells were incubated at 37°C for 40h with vehicle control (0 μM) and different concentrations of sodium salicylate (ab120746). Decreased expression of scavenging receptor SR-BI (ab52629) in THP1 cells correlates with an increase in sodium salicylate concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab52629 at 1/2000 dilution and ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.
- Chemical Structure
Lab
Chemical Structure - Sodium salicylate, anti-inflammatory agent (AB120746)
2D chemical structure image of ab120746, Sodium salicylate, anti-inflammatory agent
Complementary Products
Biochemicals
AB146713
AICAR (Acadesine/AICA riboside) (mM/ml), AMP-activated protein kinase activator
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Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Publications (1)
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Biochemical pharmacology 154:318-334 PubMed29800556
2018
Applications
Unspecified application
Species
Unspecified reactive species
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