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AB141966

Sorafenib, multikinase inhibitor

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MW 464.8 Da, Purity >98%. Potent multikinase inhibitor that targets the RAF/MEK/ERK pathway in tumor cells, and tyrosine kinases involved in tumor angiogenesis, oncogenesis, and maintenance of the tumor microenvironment. Inhibits Raf-1, B-Raf, VEGFR-2, VEGFR-3, PDGFR-β, Flt3, c-KIT and FGFR-1 (IC50 values are 6 nM, 22 nM, 90 nM, 20 nM, 57 nM, 58 nM, 68 nM and 580 nM in cell-free assays, respectively).
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Chemical Structure - Sorafenib, multikinase inhibitor (AB141966)
  • Chemical Structure

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Chemical Structure - Sorafenib, multikinase inhibitor (AB141966)

2D chemical structure image of ab141966, Sorafenib, multikinase inhibitor

Key facts

CAS number

284461-73-0

Purity

>98%

Form

Solid

form

Molecular weight

464.8 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>1</sub><sub>6</sub>ClF<sub>3</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

216239

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Sorafenib

Biological description

Potent multikinase inhibitor that targets the RAF/MEK/ERK pathway in tumor cells, and tyrosine kinases involved in tumor angiogenesis, oncogenesis, and maintenance of the tumor microenvironment. Inhibits Raf-1, B-Raf, VEGFR-2, VEGFR-3, PDGFR-β, Flt3, c-KIT and FGFR-1 (IC50 values are 6 nM, 22 nM, 90 nM, 20 nM, 57 nM, 58 nM, 68 nM and 580 nM in cell-free assays, respectively).

Canonical smiles

CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

InChi

InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

InChiKey

MLDQJTXFUGDVEO-UHFFFAOYSA-N

IUPAC Name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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