Sotrastaurin, pan-PKC inhibitor

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MW 438.5 Da, Purity >99%. Potent, selective pan-PKC inhibitor (K_i values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM for PKCα, βI, δ, ε, η, and θ respectively in a cell-free assay). Prevents the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. Displays potential immunosuppressive activity.

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1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, Glucocorticoid inducible P450, HLP, KPCA_HUMAN, KPCL_HUMAN, KPCT_HUMAN, MGC 5363, MGC126514, MGC126680, MGC141919, MGC26269, NF 25, Nifedipine oxidase, OTTHUMP00000043364, OTTHUMP00000043365, Oncogene PIM 1, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PIM, PIM1_HUMAN, PKC 0, PKC 2, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC h, PKC-A, PKC-B, PKC-L, PKC-alpha, PKC-beta, PKC-gamma, PKCE, PKCG, PRKC D, PRKCA, PRKCB, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCL, PRKCT, PRKCZ, Pim 1 kinase, Pim 1 oncogene, Prkch, Prkcq, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C epsilon, Protein kinase C eta, Protein kinase C eta type, Protein kinase C gamma, Protein kinase C theta, Protein kinase C theta type, Protein kinase C zeta, Proto-oncogene serine/threonine-protein kinase Pim-1, Proviral integration site 1, Proviral integration site 2, Quinine 3-monooxygenase, Taurochenodeoxycholate 6-alpha-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, nPKC-eta, nPKC-theta, pim 1 kinase 44 kDa isoform, pim 1 oncogene (proviral integration site 1)