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AB254459

SP-2509, LSD1 inhibitor

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MW 437.9 Da, Purity >98%. Potent, selective (IC50 = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A). No activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase.

View Alternative Names

AOF2, Amine oxidase (flavin containing) domain 2, Amine oxidase, flavin containing, 2, BHC110, BRAF35-HDAC complex protein BHC110, BRAF35/HDAC complex, 110-kD subunit, CPRF, EC1, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit, Flavin-containing amine oxidase domain-containing protein 2, KDM 1, KDM1A_HUMAN, KIAA0601, LSD 1, Lysine (K) specific demethylase 1, Lysine (K) specific demethylase 1A, Lysine demethylase 1A, Lysine-specific demethylase 1, Lysine-specific demethylase 1A, Lysine-specific histone demethylase 1, Lysine-specific histone demethylase 1A

1 Images
Chemical Structure - SP-2509, LSD1 inhibitor (AB254459)
  • Chemical Structure

Supplier Data

Chemical Structure - SP-2509, LSD1 inhibitor (AB254459)

2D chemical structure image of ab254459, SP-2509, LSD1 inhibitor

Key facts

CAS number

1423715-09-6

Purity

>98%

Form

Solid

form

Molecular weight

437.9 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>0</sub>ClN<sub>3</sub>O<sub>5</sub>S

PubChem

135743577

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

(E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide

Biological description

Potent, selective (IC50 = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A). No activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase.

Canonical smiles

CC(=NNC(=O)C1=CC(=CC=C1)S(=O)(=O)N2CCOCC2)C3=C(C=CC(=C3)Cl)O

Isomeric smiles

C/C(=N\NC(=O)C1=CC(=CC=C1)S(=O)(=O)N2CCOCC2)/C3=C(C=CC(=C3)Cl)O

InChi

InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)/b21-13+

InChiKey

NKUDGJUBIVEDTF-FYJGNVAPSA-N

IUPAC Name

N-[(E)-1-(5-chloro-2-hydroxyphenyl)ethylideneamino]-3-morpholin-4-ylsulfonylbenzamide

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Biochemicals

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Biochemicals

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Primary Antibodies

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Assay Kits

AB133060

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Sandwich ELISA - HSP70 ELISA Kit (AB133060)

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Product details

Solutions in DMSO may be stored at -20°C for up to 3 months.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
-20°C
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Refer to SDS for further information.

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Product protocols

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