MW 220.23 Da, Purity >99%. Potent and selective JNK1, -2, and -3 inhibitor (IC50 = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
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- PLoS pathogens 19:e10111342023Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLu Zhang,Wenwen Liu,Nan Wu,Hui Wang,Zhongkai Zhang,Yule Liu,Xifeng WangPubMed 36706154
- The Tohoku journal of experimental medicine 259:209-2192022Effects of Holliday Junction-Recognition Protein-Mediated C-Jun N-Terminal Kinase/ Signal Transducer and Activator of Transcription 3 Signaling Pathway on Cell Proliferation, Cell Cycle and Cell Apoptosis in Bladder Urothelial Carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSong Gao,Xiao-Qing Zhou,Qi Wu,Xue-Dong Chen,Peng Li,Ye-Min QinPubMed 36543245
- Journal of food biochemistry 46:e144632022Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Zhang,Jian Ping,Na Jiang,Lieming XuPubMed 36314441
- World journal of gastroenterology 28:4649-46672022Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTomoyuki Fukami,Atsushi Shiozaki,Toshiyuki Kosuga,Michihiro Kudou,Hiroki Shimizu,Takuma Ohashi,Tomohiro Arita,Hirotaka Konishi,Shuhei Komatsu,Takeshi Kubota,Hitoshi Fujiwara,Kazuma Okamoto,Mitsuo Kishimoto,Yukiko Morinaga,Eiichi Konishi,Eigo OtsujiPubMed 36157935
- Glia 70:1850-18632022CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria P Ivshina,Heleen M van 't Spijker,Suna Jung,Sithara Raju Ponny,Dorothy P Schafer,Joel D RichterPubMed 35635122
- Frontiers in physiology 13:8232752022Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human Odontogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoxiao Hu,Chensheng Lin,Ningsheng Ruan,Zhen Huang,Yanding Zhang,Xuefeng HuPubMed 35211032
- Molecular medicine reports 25:2022Exenatide exerts a neuroprotective effect against diabetic cognitive impairment in rats by inhibiting apoptosis: Role of the JNK/c‑JUN signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGengyin Wang,Zongquan Zhao,Bo Ren,Wu Yu,Xudong Zhang,Jiang Liu,Liping Wang,Daowen Si,Meiliu YangPubMed 35119079
- Frontiers in immunology 12:7558622021Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoão Paulo Silva Nunes,Pauline Andrieux,Pauline Brochet,Rafael Ribeiro Almeida,Eduardo Kitano,André Kenji Honda,Leo Kei Iwai,Débora Andrade-Silva,David Goudenège,Karla Deysiree Alcântara Silva,Raquel de Souza Vieira,Débora Levy,Sergio Paulo Bydlowski,Frédéric Gallardo,Magali Torres,Edimar Alcides Bocchi,Miguel Mano,Ronaldo Honorato Barros Santos,Fernando Bacal,Pablo Pomerantzeff,Francisco Rafael Martins Laurindo,Priscila Camillo Teixeira,Helder I Nakaya,Jorge Kalil,Vincent Procaccio,Christophe Chevillard,Edecio Cunha-NetoPubMed 34867992
- Molecular medicine reports 24:2021MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChun-Na Lan,Wei-Jun Cai,Jie Shi,Zhong-Jie YiPubMed 34590154
- Aging cell 20:e134682021Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoids.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJulio Aguado,Harman K Chaggar,Cecilia Gómez-Inclán,Mohammed R Shaker,Hannah C Leeson,Alan Mackay-Sim,Ernst J WolvetangPubMed 34459078
Key facts
- CAS number
- 129-56-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 220.23 Da
- Molecular formula
- C14H8N2O
- PubChem identifier
- 8515
- Nature
- Synthetic
Alternative names
AI849689, C Jun kinase 2, C-JUN kinase 1, EC 2.7.11.24, FLJ12099, FLJ33785, JNK, JNK 1, JNK 2, JNK-46, JNK-55, JNK1A2, JNK2 alpha, JNK2 beta, JNK21B1/2, JNK2A, JNK2B, JNK3, JNK3 alpha protein kinase, JNK3A, Jun kinase, MAP Kinase, MAP kinase 10, MAP kinase 8, MAP kinase 9, MAP kinase p49 3F12, MAPK 10, MAPK 8, MAPK 9, MGC50974, MK08_HUMAN, MK09_HUMAN, MK10_HUMAN, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, P54a, PRKM 8, PRKM 9, PRKM10, Protein kinase JNK1, Protein kinase, mitogen-activated, 8, Protein kinase, mitogen-activated, 9, SAPK, SAPK 1, SAPK alpha, SAPK gamma, SAPK1a, SAPK1b, Stress activated protein kinase beta, Stress-activated protein kinase 1, Stress-activated protein kinase 1a, Stress-activated protein kinase 1b, Stress-activated protein kinase JNK1, Stress-activated protein kinase JNK2, Stress-activated protein kinase JNK3, c Jun kinase 3, c-Jun N-terminal kinase 1, c-Jun N-terminal kinase 2, c-Jun N-terminal kinase 3, p493F12, p54 gamma, p54aSAPK, p54bSAPK, protein kinase mitogen activated 10
Recommended products
MW 220.23 Da, Purity >99%. Potent and selective JNK1, -2, and -3 inhibitor (IC50 = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
Key facts
- CAS number
- 129-56-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 220.23 Da
- Molecular formula
- C14H8N2O
- PubChem identifier
- 8515
- Nature
- Synthetic
- Biochemical name
- 1,9-Pyrazoloanthrone
- Biological description
Potent and selective JNK1, -2, and -3 inhibitor (IC50 = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
- Canonical SMILES
- C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
- InChI
- InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
- InChIKey
- ACPOUJIDANTYHO-UHFFFAOYSA-N
- IUPAC name
- 14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The JNK protein family also known as c-Jun N-terminal kinases consists of JNK1 JNK2 and JNK3. These proteins are mitogen-activated protein kinases (MAPKs) that play a role in transmitting extracellular signals to the cell nucleus. JNK1 has a mass of approximately 54 kDa and is ubiquitously expressed in various tissues. JNK2 is similar in mass and expression while JNK3 is primarily found in the brain heart and testes. These proteins can phosphorylate transcription factors such as c-Jun impacting gene expression processes.
- Biological function summary
The JNK proteins are involved in controlling cellular events like proliferation differentiation and apoptosis. They act as part of the MAPK signaling complex and involve scaffolding proteins that help organize these signaling pathways. In the cellular context JNK proteins are activated in response to stress signals like UV irradiation inflammatory cytokines and growth factors. This activation leads to diverse cellular outcomes depending on the specific JNK isoform and cell type.
- Pathways
The JNK proteins are important in the MAPK signaling pathways and play a role in the AP-1 transcription factor regulation. They interact with proteins such as MEK4 and MEK7 which are upstream kinases that activate JNK through phosphorylation. The JNK signaling arm is distinct from the ERK and p38 MAPK pathways each having specific roles in cellular response modulation.
- Associated diseases and disorders
The JNK proteins are implicated in conditions like neurodegenerative diseases and cancer. In Alzheimer's disease for example JNK3 contributes to neuronal cell death while JNK inhibitors like SP600125 have been explored for therapeutic potential. In cancer JNK proteins can influence tumor progression through the regulation of apoptosis and their activity may intersect with other kinases like p53 further complicating disease pathways. JNK's role in diseases makes it a critical target for developing inhibitors reflected in studies around compounds like JNK inhibitor 8 and related molecules.
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Chemical Structure - SP600125, JNK inhibitor (ab120065)
2D chemical structure image of ab120065, SP600125, JNK inhibitor
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