SP600125, JNK inhibitor

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(40 Publications)

MW 220.23 Da, Purity >99%. Potent and selective JNK1, -2, and -3 inhibitor (IC₅₀ = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.

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AI849689, C Jun kinase 2, C-JUN kinase 1, EC 2.7.11.24, FLJ12099, FLJ33785, JNK, JNK 1, JNK 2, JNK-46, JNK-55, JNK1A2, JNK2 alpha, JNK2 beta, JNK21B1/2, JNK2A, JNK2B, JNK3, JNK3 alpha protein kinase, JNK3A, Jun kinase, MAP Kinase, MAP kinase 10, MAP kinase 8, MAP kinase 9, MAP kinase p49 3F12, MAPK 10, MAPK 8, MAPK 9, MGC50974, MK08_HUMAN, MK09_HUMAN, MK10_HUMAN, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, P54a, PRKM 8, PRKM 9, PRKM10, Protein kinase JNK1, Protein kinase, mitogen-activated, 8, Protein kinase, mitogen-activated, 9, SAPK, SAPK 1, SAPK alpha, SAPK gamma, SAPK1a, SAPK1b, Stress activated protein kinase beta, Stress-activated protein kinase 1, Stress-activated protein kinase 1a, Stress-activated protein kinase 1b, Stress-activated protein kinase JNK1, Stress-activated protein kinase JNK2, Stress-activated protein kinase JNK3, c Jun kinase 3, c-Jun N-terminal kinase 1, c-Jun N-terminal kinase 2, c-Jun N-terminal kinase 3, p493F12, p54 gamma, p54aSAPK, p54bSAPK, protein kinase mitogen activated 10