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AB142205

Spautin-1, USP10 and USP13 inhibitor

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MW 271.26 Da, Purity >97%. Cell-permeable USP10 and USP13 inhibitor. Blocks autophagy. Active in vivo. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

Deubiquitinating enzyme 10, Deubiquitinating enzyme 13, ISOT-3, Isopeptidase T-3, KIAA0190, MGC124997, MGC2621, UBP10_HUMAN, UBP13_HUMAN, UBPO, Ubiquitin carboxyl-terminal hydrolase 10, Ubiquitin carboxyl-terminal hydrolase 13, Ubiquitin specific peptidase 10, Ubiquitin specific peptidase 13, Ubiquitin specific peptidase 13 (isopeptidase T3), Ubiquitin specific protease 10, Ubiquitin specific protease 13, Ubiquitin thioesterase 10, Ubiquitin thioesterase 13, Ubiquitin thiolesterase 10, Ubiquitin thiolesterase 13, Ubiquitin-specific-processing protease 10, Ubiquitin-specific-processing protease 13

1 Images
Chemical Structure - Spautin-1, USP10 and USP13 inhibitor (AB142205)
  • Chemical Structure

Lab

Chemical Structure - Spautin-1, USP10 and USP13 inhibitor (AB142205)

2D chemical structure image of ab142205, Spautin-1, USP10 and USP13 inhibitor

Key facts

CAS number

1262888-28-7

Purity

>97%

Form

Solid

form

Molecular weight

271.26 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>1</sub>F<sub>2</sub>N<sub>3</sub>

PubChem

51037431

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine

Biological description

Cell-permeable USP10 and USP13 inhibitor. Blocks autophagy. Active in vivo.

Canonical smiles

C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F

InChi

InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)

InChiKey

AWIVHRPYFSSVOG-UHFFFAOYSA-N

IUPAC Name

6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2037 Spautin-1. 2037-25 is the same size as the 25 mg size of ab142205.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

USP10 and USP13 are deubiquitinating enzymes important in the regulation of protein degradation. USP10 also known as ubiquitin specific peptidase 10 has a mass of approximately 94 kDa and is expressed in both the cytoplasm and nucleus of cells. USP13 or ubiquitin specific peptidase 13 weighs around 97 kDa and shows expression in various tissues including the heart brain and testis. Both are involved in removing ubiquitin from target proteins preventing their degradation by the proteasome.
Biological function summary

Both USP10 and USP13 play roles in controlling the stability of key regulatory proteins which affects cell growth DNA repair and apoptosis. USP10 participates in the stabilization of p53 by deubiquitinating it leading to its increased half-life and activity. USP13 is known for stabilizing the E3 ubiquitin-protein ligase Mdm2 which affects p53 regulation as well. These proteins are not usually considered part of a larger complex but interact with several important cellular components to exert influence on cellular processes.

Pathways

Researchers have identified USP10 and USP13 as significant in the ubiquitin-proteasome pathway and DNA damage response. USP10 has connections to the PI3K/AKT signaling pathway through its action on PTEN and its interactions with oncogenic proteins. USP13 communicates with the same pathway by influencing Mdm2 stability which affects p53-mediated pathways. Both proteins are involved in maintaining cellular homeostasis by modulating the degradation and recycling of protein complexes.

USP10 and USP13 have implications in cancer and neurodegenerative diseases. Abnormal regulation of USP10 can lead to various cancers due to its effect on stabilizing oncogenes or tumor suppressors like p53. Its interaction with PTEN can impact cancer progression. USP13's role in neurodegenerative diseases is linked to its function in protein homeostasis and the ubiquitin-proteasome system which may affect proteins like tau in Alzheimer's disease. Changes in these enzymes can influence disease progression and patient outcomes.
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Product protocols

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