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AB120642

SQ 22536, Non-competitive adenylyl cyclase inhibitor

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(6 Publications)

MW 205.22 Da, Purity >99%. Non-competitive adenylyl cyclase inhibitor. Inhibits catecholamine stimulated cAMP production (IC50 values are 0.08-1.45 and 0.08-0.27 mM in catfish and rat hepatocyte cell membranes, respectively). Inhibits muscarinic Ca2+ signalling in rat carotid bodies in vitro.
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Chemical Structure - SQ 22536, Non-competitive adenylyl cyclase inhibitor (AB120642)
  • Chemical Structure

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Chemical Structure - SQ 22536, Non-competitive adenylyl cyclase inhibitor (AB120642)

2D chemical structure image of ab120642, SQ 22536, Non-competitive adenylyl cyclase inhibitor

Key facts

CAS number

17318-31-9

Purity

>99%

Form

Solid

form

Molecular weight

205.22 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>1</sub>N<sub>5</sub>O

PubChem

5270

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

9-(Tetrahydrofuran-2-yl)-9h-purin-6-amine

Biological description

Non-competitive adenylyl cyclase inhibitor. Inhibits catecholamine stimulated cAMP production (IC50 values are 0.08-1.45 and 0.08-0.27 mM in catfish and rat hepatocyte cell membranes, respectively). Inhibits muscarinic Ca2+ signalling in rat carotid bodies in vitro.

Canonical smiles

C1CC(OC1)N2C=NC3=C(N=CN=C32)N

InChi

InChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)

InChiKey

UKHMZCMKHPHFOT-UHFFFAOYSA-N

IUPAC Name

9-(oxolan-2-yl)purin-6-amine

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Product details

This compound appears to be unstable in strongly acidic solutions. We therefore recommend avoiding exposure to low pH.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:9887 PubMed39543166

2024

Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Yang,Mengdi Zhang,Yuan Zhou,Dongxiao Jiang,Lilong Yu,Lingyu Xu,Fan Fei,Wenkai Lin,Yanrong Zheng,Jiannong Wu,Yi Wang,Zhong Chen

Cells 11: PubMed36359914

2022

Dynamic Balance between PTH1R-Dependent Signal Cascades Determines Its Pro- or Anti-Osteogenic Effects on MSC.

Applications

Unspecified application

Species

Unspecified reactive species

Konstantin Kulebyakin,Pyotr Tyurin-Kuzmin,Leila Sozaeva,Nikita Voloshin,Mikhail Nikolaev,Vadim Chechekhin,Maxim Vigovskiy,Veronika Sysoeva,Elizaveta Korchagina,Daria Naida,Maria Vorontsova

Bone 135:115305 PubMed32126313

2020

Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs.

Applications

Unspecified application

Species

Unspecified reactive species

Subhashis Pal,Mamunur Rashid,Sandeep Kumar Singh,Konica Porwal,Priya Singh,Riyazuddin Mohamed,Jiaur R Gayen,Muhammad Wahajuddin,Naibedya Chattopadhyay

Frontiers in physiology 9:456 PubMed29867524

2018

Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lea Weber,Wolfgang A Schulz,Stathis Philippou,Josephine Eckardt,Burkhard Ubrig,Michéle J Hoffmann,Andrea Tannapfel,Benjamin Kalbe,Günter Gisselmann,Hanns Hatt

Lipids in health and disease 15:213 PubMed27938411

2016

Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2-mediated and prostaglandin E2-mediated pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Hideo Ohira,Wao Tsutsui,Rie Mamoto,Sayaka Yamaguchi,Masako Nishida,Miki Ito,Yoshio Fujioka

Scientific reports 6:32835 PubMed27596381

2016

Activation of β-adrenergic receptors is required for elevated α1A-adrenoreceptors expression and signaling in mesenchymal stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Pyotr A Tyurin-Kuzmin,Julia I Fadeeva,Margarita A Kanareikina,Natalia I Kalinina,Veronika Yu Sysoeva,Daniyar T Dyikanov,Dmitriy V Stambolsky,Vsevolod A Tkachuk
View all publications
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