SR 27897 (Lintitript), CCK1 receptor antagonist
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MW 411.9 Da, Purity >98%. Highly potent, selective, competitive, non-peptide CCK1 receptor antagonist (Ki = 0.2 nM). Increases plasma leptin levels. Shows central effects. Stimulates food intake *in vivo.* Orally active.
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1 25 dihydroxyvitamin D3 receptor, 25-dihydroxyvitamin D3 receptor, AP-1, Activator protein 1, BXR, CCK A, CCK-A receptor, CCK1-R, CCKAR_HUMAN, CCKR Type A, CCKRA, Cholecystokinin A receptor, Cholecystokinin receptor type A, Cholecystokinin type A receptor, Cholecystokinin-1 receptor, Deubiquitinating enzyme 1, Enhancer Binding Protein AP1, JUN protein, JUNC, JUN_HUMAN, Jun Activation Domain Binding Protein, Jun oncogene, Jun proto oncogene, Member 1, NF-E2-related factor 2, NF2L2_HUMAN, NR1C3, NR1I1, NR1I2_HUMAN, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor subfamily 1 group C member 3, Nuclear receptor subfamily 1 group I member 1, Nuclear receptor subfamily 1 group I member 2, ONR 1, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene JUN, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, PAR, PAR q, PPAR-gamma, PPARG2, PPARG_HUMAN, PPP1R163, PRR, Peroxisome proliferator activated receptor gamma 2, Peroxisome proliferator-activated receptor gamma, Pregnane X receptor, Protein phosphatase 1, regulatory subunit 163, Proto-oncogene c-jun, SXR, Steroid and xenobiotic receptor, TRFR_HUMAN, TRH Receptor, TRH-R, Thyroliberin receptor, Thyrotropin-releasing hormone receptor, Transcription factor AP-1, UBP, UBP1_HUMAN, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin specific peptidase 1, Ubiquitin specific protease 1, Ubiquitin thioesterase 1, Ubiquitin thiolesterase 1, Ubiquitin-specific-processing protease 1, V jun sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V-jun avian sarcoma virus 17 oncogene homolog, VDR_HUMAN, Vitamin D (1,25- dihydroxyvitamin D3) receptor, Vitamin D hormone receptor, Vitamin D nuclear receptor variant 1, Vitamin D receptor, Vitamin D3 receptor, cJun, erythroid derived 2, hUBP, like 2, nuclear factor erythroid 2 like 2, p39, pregnane X nuclear receptor variant 2
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Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins influence substantial aspects of cellular function and metabolism. c-Jun forms part of the AP-1 complex impacting cellular proliferation and apoptosis. Vitamin D Receptor modulates gene expression related to immune responses and bone development. PPAR gamma 2 influences fat storage and glucose metabolism. PXR regulates the expression of enzymes involved in drug metabolism. TRH-R and CCK1-R transmit signals essential for hormone-mediated physiological responses. USP1 contributes to DNA repair and maintaining genomic stability. Nrf2 when activated translocates to the nucleus to initiate the transcription of antioxidant response genes working alongside enzymes such as HO-1.
Pathways
These proteins integrate into significant metabolic and regulatory networks. c-Jun influences the MAPK signaling pathway associating closely with proteins like JNK. Vitamin D Receptor plays an important role in the calcium signaling pathway and interacts with retinoid X receptors. PPAR gamma 2 aligns with adipogenesis pathways and cross-talks with insulin signaling. PXR integrates into the detoxification pathway often synergizing with cytochrome P450 enzymes. TRH-R and CCK1-R operate within the neuroendocrine signaling pathways. USP1 functions within the DNA damage response pathway working with PCNA and FANCD2. Nrf2 is principally involved in the oxidative stress pathway collaborating with proteins like KEAP1.
Product promise
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