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AB146173

SR-8278, REV-ERBalpha antagonist

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MW 361.5 Da. REV-ERBα antagonist (EC50 = 470 nM, REV-ERBα transcriptional repression activity). Stimulates the expression of gluconeogenesis genes G6Pase and PEPCK.
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Chemical Structure - SR-8278, REV-ERBalpha antagonist (AB146173)
  • Chemical Structure

Lab

Chemical Structure - SR-8278, REV-ERBalpha antagonist (AB146173)

2D chemical structure image of ab146173, SR-8278, REV-ERBalpha antagonist

Key facts

CAS number

1254944-66-5

Molecular weight

361.5 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>9</sub>NO<sub>3</sub>S<sub>2</sub>

PubChem

53393127

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 25 mM

Biochemical name

Ethyl 2-{[5-(methylsulfanyl)thiophen-2-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Biological description

REV-ERBα antagonist (EC50 = 470 nM, REV-ERBα transcriptional repression activity). Stimulates the expression of gluconeogenesis genes G6Pase and PEPCK.

Canonical smiles

CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC

InChi

InChI=1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3

InChiKey

UIEBLUZPSFAFOC-UHFFFAOYSA-N

IUPAC Name

ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Complementary Products

Biochemicals

AB146174

SR-9009, REV-ERBalpha/beta agonist

Chemical Structure - SR-9009, REV-ERBalpha/beta agonist (AB146174)

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Primary Antibodies

AB174309

Anti-NR1D1 + NR1D2 / RVR antibody [EPR10376]

RabMAb|Recombinant

Western blot - Anti-NR1D1 + NR1D2 / RVR antibody [EPR10376] (AB174309)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB136451

Anti-PER1 antibody - N-terminal

Western blot - Anti-PER1 antibody - N-terminal (AB136451)

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