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AB141462

SR1001, RORalpha and RORgammat inverse agonist

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(1 Publication)

MW 477.4 Da, Purity >98%. Potent, selective RORα and RORγt inverse agonist (Ki values are 172 and 111 nM for RORα and RORγ respectively). Suppresses IL-17 promoter driven transcriptional activity. Inhibits TRAP220 nuclear receptor box 2 peptide interaction (IC50 = 117 nM). Shows immunosuppressant effects in vivo..

View Alternative Names

IMD42, MGC129539, NR1F1, NR1F3, Nuclear receptor ROR-alpha, Nuclear receptor ROR-gamma, Nuclear receptor RZR-alpha, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 1, Nuclear receptor subfamily 1 group F member 3, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor alpha, RAR related orphan receptor gamma, RAR-related orphan receptor A, RAR-related orphan receptor C, RORA_HUMAN, RORG_HUMAN, RZR GAMMA, RZR-ALPHA, RZRA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-alpha, Retinoid-related orphan receptor-gamma, Rorc, TOR, Transcription factor RZR alpha, fhl2a

1 Images
Chemical Structure - SR1001, RORalpha and RORgammat inverse agonist (AB141462)
  • Chemical Structure

Lab

Chemical Structure - SR1001, RORalpha and RORgammat inverse agonist (AB141462)

2D chemical structure image of ab141462, SR1001, RORalpha and RORgammat inverse agonist

Key facts

CAS number

1335106-03-0

Purity

>98%

Form

Solid

form

Molecular weight

477.4 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>3</sub>F<sub>6</sub>N<sub>3</sub>O<sub>4</sub>S<sub>2</sub>

PubChem

44241473

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

N-[5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]sulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide

Biological description

Potent, selective RORα and RORγt inverse agonist (Ki values are 172 and 111 nM for RORα and RORγ respectively). Suppresses IL-17 promoter driven transcriptional activity. Inhibits TRAP220 nuclear receptor box 2 peptide interaction (IC50 = 117 nM). Shows immunosuppressant effects in vivo.

Canonical smiles

CC1=C(SC(=N1)NC(=O)C)S(=O)(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O

InChi

InChI=1S/C15H13F6N3O4S2/c1-7-11(29-12(22-7)23-8(2)25)30(27,28)24-10-5-3-9(4-6-10)13(26,14(16,17)18)15(19,20)21/h3-6,24,26H,1-2H3,(H,22,23,25)

InChiKey

OZBSSKGBKHOLGA-UHFFFAOYSA-N

IUPAC Name

N-[5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]sulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1902 SR1001. 1902-25 is the same size as the 25 mg size of ab141462.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 9:e20118 PubMed37809525

2023

Fasudil and SR1001 synergistically protect against sepsis-associated pancreatic injury by inhibiting RhoA/ROCK pathway and Th17/IL-17 response.

Applications

Unspecified application

Species

Unspecified reactive species

Pingping Liu,Zhenghui Xiao,Xiulan Lu,Xinping Zhang,Jiaotian Huang,Cheng Li
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