SR95531 (Gabazine), GABAA antagonist

• Chemical Structure

Lab

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

2D chemical structure image of ab120042, SR95531 (Gabazine), GABAA antagonist

• FuncS

PubMed

Functional Studies - SR95531 (Gabazine), GABAA antagonist (AB120042)

A. Purkinje cell response to simulated ischemia (OGD only) in the continuous presence of the GABAA antagonist GABAzine (ab120042, 10 μM), and during subsequent block of glutamate receptors with AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM). B. Bar charts summarize the timing and magnitude of ischemia-induced glutamate currents (for both methods of simulating ischemia) with and without GABAA receptors blocked. Iglu is the magnitude of current blocked by AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM).

Image from Brady JD et al., Neuroscience. 2010;168(1):108-17. Fig 3.; doi: 10.1016/j.neuroscience.2010.03.009 with permission from Elsevier.

• CellAct

Unknown

Cellular Activation - SR95531 (Gabazine), GABAA antagonist (AB120042)

Expression of DISC1ΔC is induced by postnatal administration of 4-OHT as seen by expression of GFP fused to DISC1ΔC in this P28 brain slice. No GFP expression is observed in vehicle treated animals (- 4-OHT). Scale bar equals 100 μm. Performed in the presence of gabazine (5 μM) and TTX (1 μM).

Image from Maher BJ, LoTurco JJ, Plos One, 7(3), e34053. Fig 1,; doi: 10.1371/journal.pone.0034053