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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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MW 368.23 Da, Purity >98%. Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Soluble in 1 ml water to give specified mM/ml concentration.
104104-50-9
> 98%
Solid
368.23 Da
C15H18BrN3O3
107895
Synthetic
AW061132, B230208N19Rik, CAE 2, ECA 2, ECA4, ECA5, EIEE19, EJM, EJM5, GAA 5, GABA, GABA A, GABA A Receptor alpha 3, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA alpha receptor beta-2 subunit, GABA subunit A receptor alpha 6, GABA(A) receptor, GABA(A) receptor beta 1, GABA(A) receptor beta 2, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-3, GABA(A) receptor subunit alpha-4, GABA(A) receptor subunit alpha-5, GABA(A) receptor subunit alpha-6, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit beta-3, GABA(A) receptor subunit delta, GABA(A) receptor subunit gamma-1, GABA(A) receptor subunit gamma-2, GABA(A) receptor subunit gamma-3, GABA(A) receptor subunit pi, GABA(A) receptor, alpha 1, GABA-A receptor, beta-1 polypeptide, GABA-A receptor, beta-2 polypeptide, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 3, GABR A3, GABR B3, GABR G3, GABRA 1, GABRA 5, GABRA 6, GABRB2, GABRG 1, GABRG 2, GABRP, GARB1, GBRA1_HUMAN, GBRA3_HUMAN, GBRA4_HUMAN, GBRA5_HUMAN, GBRA6_HUMAN, GBRB1_HUMAN, GBRB2_HUMAN, GBRB3_HUMAN, GBRD_HUMAN, GBRG1_HUMAN, GBRG2_HUMAN, GBRG3_HUMAN, GBRP_HUMAN, GC138184, GEFSP 3, Gaba receptor alpha 1 polypeptide, GabaA/BZ, Gamma Aminobutyric Acid A Receptor Beta 1, Gamma Aminobutyric Acid Receptor , beta-1, Gamma aminobutyric acid (GABA A) receptor subunit gamma 1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 3, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid (GABA) A receptor beta 1, Gamma aminobutyric acid (GABA) A receptor beta 3, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor gamma 3, Gamma aminobutyric acid (GABA) A receptor pi, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 3, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid A receptor, gamma 1, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid GABA A receptor delta, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-6, Gamma-aminobutyric acid receptor subunit beta-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Gamma-aminobutyric acid receptor subunit gamma-1, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit pi, Gamma-aminobutyric-acid receptor subunit beta-2, MGC116903, MGC116904, MGC126386, MGC126387, MGC33793, MGC45284, MGC9051
MW 368.23 Da, Purity >98%. Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Soluble in 1 ml water to give specified mM/ml concentration.
AW061132, B230208N19Rik, CAE 2, ECA 2, ECA4, ECA5, EIEE19, EJM, EJM5, GAA 5, GABA, GABA A, GABA A Receptor alpha 3, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA alpha receptor beta-2 subunit, GABA subunit A receptor alpha 6, GABA(A) receptor, GABA(A) receptor beta 1, GABA(A) receptor beta 2, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-3, GABA(A) receptor subunit alpha-4, GABA(A) receptor subunit alpha-5, GABA(A) receptor subunit alpha-6, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit beta-3, GABA(A) receptor subunit delta, GABA(A) receptor subunit gamma-1, GABA(A) receptor subunit gamma-2, GABA(A) receptor subunit gamma-3, GABA(A) receptor subunit pi, GABA(A) receptor, alpha 1, GABA-A receptor, beta-1 polypeptide, GABA-A receptor, beta-2 polypeptide, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 3, GABR A3, GABR B3, GABR G3, GABRA 1, GABRA 5, GABRA 6, GABRB2, GABRG 1, GABRG 2, GABRP, GARB1, GBRA1_HUMAN, GBRA3_HUMAN, GBRA4_HUMAN, GBRA5_HUMAN, GBRA6_HUMAN, GBRB1_HUMAN, GBRB2_HUMAN, GBRB3_HUMAN, GBRD_HUMAN, GBRG1_HUMAN, GBRG2_HUMAN, GBRG3_HUMAN, GBRP_HUMAN, GC138184, GEFSP 3, Gaba receptor alpha 1 polypeptide, GabaA/BZ, Gamma Aminobutyric Acid A Receptor Beta 1, Gamma Aminobutyric Acid Receptor , beta-1, Gamma aminobutyric acid (GABA A) receptor subunit gamma 1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 3, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid (GABA) A receptor beta 1, Gamma aminobutyric acid (GABA) A receptor beta 3, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor gamma 3, Gamma aminobutyric acid (GABA) A receptor pi, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 3, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid A receptor, gamma 1, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid GABA A receptor delta, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-6, Gamma-aminobutyric acid receptor subunit beta-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Gamma-aminobutyric acid receptor subunit gamma-1, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit pi, Gamma-aminobutyric-acid receptor subunit beta-2, MGC116903, MGC116904, MGC126386, MGC126387, MGC33793, MGC45284, MGC9051
104104-50-9
> 98%
Solid
368.23 Da
C15H18BrN3O3
107895
Synthetic
1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide
Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Soluble in 1 ml water to give specified mM/ml concentration.
COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br
InChI=1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H
GFZHNFOGCMEYTA-UHFFFAOYSA-N
4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide
Ambient - Can Ship with Ice
+4°C
Store under desiccating conditions, The product can be stored for up to 12 months
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Terms & Conditions.
2D chemical structure image of ab120042, SR95531 (Gabazine), GABAA antagonist
Expression of DISC1ΔC is induced by postnatal administration of 4-OHT as seen by expression of GFP fused to DISC1ΔC in this P28 brain slice. No GFP expression is observed in vehicle treated animals (- 4-OHT). Scale bar equals 100 μm. Performed in the presence of gabazine (5 μM) and TTX (1 μM).
A. Purkinje cell response to simulated ischemia (OGD only) in the continuous presence of the GABAA antagonist GABAzine (ab120042, 10 μM), and during subsequent block of glutamate receptors with AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM). B. Bar charts summarize the timing and magnitude of ischemia-induced glutamate currents (for both methods of simulating ischemia) with and without GABAA receptors blocked. Iglu is the magnitude of current blocked by AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM).
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