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MW 368.23 Da, Purity >98%. Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.

Soluble in 1 ml water to give specified mM/ml concentration.

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Key facts

CAS number

104104-50-9

Purity

> 98%

Form

Solid

Molecular weight

368.23 Da

Molecular formula

C15H18BrN3O3

PubChem identifier

107895

Nature

Synthetic

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Alternative names

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MW 368.23 Da, Purity >98%. Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.

Soluble in 1 ml water to give specified mM/ml concentration.

Alternative names

Key facts

Purity

> 98%

PubChem identifier

107895

Biochemical name

1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide

Biological description

Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.

Soluble in 1 ml water to give specified mM/ml concentration.

Canonical SMILES

COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br

InChI

InChI=1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChIKey

GFZHNFOGCMEYTA-UHFFFAOYSA-N

IUPAC name

4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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Full details and terms and conditions can be found here:
Terms & Conditions.

3 product images

  • Chemical Structure - SR95531 (Gabazine), GABAA antagonist (ab120042), expandable thumbnail

    Chemical Structure - SR95531 (Gabazine), GABAA antagonist (ab120042)

    2D chemical structure image of ab120042, SR95531 (Gabazine), GABAA antagonist

  • Cellular Activation - SR95531 (Gabazine), GABAA antagonist (ab120042), expandable thumbnail
    Image from Maher BJ, LoTurco JJ, Plos One, 7(3), e34053. Fig 1,; doi: 10.1371/journal.pone.0034053

    Cellular Activation - SR95531 (Gabazine), GABAA antagonist (ab120042)

    Expression of DISC1ΔC is induced by postnatal administration of 4-OHT as seen by expression of GFP fused to DISC1ΔC in this P28 brain slice. No GFP expression is observed in vehicle treated animals (- 4-OHT). Scale bar equals 100 μm. Performed in the presence of gabazine (5 μM) and TTX (1 μM).

  • Functional Studies - SR95531 (Gabazine), GABAA antagonist (ab120042), expandable thumbnail
    Image from Brady JD et al., Neuroscience. 2010;168(1):108-17. Fig 3.; doi: 10.1016/j.neuroscience.2010.03.009 with permission from Elsevier.

    Functional Studies - SR95531 (Gabazine), GABAA antagonist (ab120042)

    A. Purkinje cell response to simulated ischemia (OGD only) in the continuous presence of the GABAA antagonist GABAzine (ab120042, 10 μM), and during subsequent block of glutamate receptors with AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM). B. Bar charts summarize the timing and magnitude of ischemia-induced glutamate currents (for both methods of simulating ischemia) with and without GABAA receptors blocked. Iglu is the magnitude of current blocked by AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM).

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Product protocols

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