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AB144487

SR95531 (Gabazine) (mM/ml), GABAA antagonist

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(56 Publications)

MW 368.23 Da, Purity >98%. Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Soluble in 1 ml water to give specified mM/ml concentration.
2 Images
Functional Studies - SR95531 (Gabazine) (mM/ml), GABAA antagonist (AB144487)
  • FuncS

PubMed

Functional Studies - SR95531 (Gabazine) (mM/ml), GABAA antagonist (AB144487)

Increased tonic GABA currents and altered IPSC properties in TC neurons of SSADH−/− mice.

C, representative current traces from thalamocortical neurons of WT (left) and SSADH−/− (right) mice showing the difference in tonic current amplitude between the two genotypes. Dotted lines represent the initial baseline current prior to the focal application of 50 μM GBZ (white bar).

GBZ = Gabazine.

(From Figure 1 of Erringtom et al).

Errington et al PLoS One. 2011; 6(4): e19021. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - SR95531 (Gabazine) (mM/ml), GABAA antagonist (AB144487)
  • Chemical Structure

Lab

Chemical Structure - SR95531 (Gabazine) (mM/ml), GABAA antagonist (AB144487)

2D chemical structure image of ab144487, SR95531 (Gabazine) (mM/ml), GABAA antagonist

Key facts

CAS number

104104-50-9

Purity

>98%

Form

Solid

form

Molecular weight

368.23 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>8</sub>BrN<sub>3</sub>O<sub>3</sub>

PubChem

107895

Nature

Synthetic

Biochemical name

1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide

Biological description

Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br

InChi

InChI=1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChiKey

GFZHNFOGCMEYTA-UHFFFAOYSA-N

IUPAC Name

4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide

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Primary Antibodies

AB252881

Anti-GFP antibody [3H9]

BOND RX™ Validated|Recombinant|Lab Essentials|Trial Size

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (56)

Recent publications for all applications. Explore the full list and refine your search

eLife 10: PubMed34787078

2021

Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chang-Rui Chen,Yu-Heng Zhong,Shan Jiang,Wei Xu,Lei Xiao,Zan Wang,Wei-Min Qu,Zhi-Li Huang

Sleep 43: PubMed31552427

2019

Lesion of intergeniculate leaflet GABAergic neurons attenuates sleep in mice exposed to light.

Applications

Unspecified application

Species

Unspecified reactive species

Huan-Ying Shi,Wei Xu,Han Guo,Hui Dong,Wei-Min Qu,Zhi-Li Huang

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:5486-98 PubMed23536064

2013

Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Giulia Quattrocolo,Gianmaria Maccaferri

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:4768-81 PubMed23486948

2013

Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse.

Applications

Unspecified application

Species

Unspecified reactive species

Pierre F Apostolides,Laurence O Trussell

The Journal of physiology 591:2541-61 PubMed23478133

2013

Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel.

Applications

Unspecified application

Species

Unspecified reactive species

Kristal Tucker,Sukhee Cho,Nicolas Thiebaud,Michael X Henderson,Debra Ann Fadool

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:1828-32 PubMed23365222

2013

Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory.

Applications

Unspecified application

Species

Unspecified reactive species

Pu-Yeh Wu,Yu-Yin Huang,Chien-Chun Chen,Tsan-Ting Hsu,Yen-Chu Lin,Ju-Yun Weng,Ta-Chun Chien,Irene H Cheng,Cheng-Chang Lien

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:1790-6 PubMed23365218

2013

Distinct modes of dopamine and GABA release in a dual transmitter neuron.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Borisovska,AeSoon L Bensen,Gene Chong,Gary L Westbrook

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:1044-9 PubMed23325242

2013

In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Marilena Griguoli,Giada Cellot,Enrico Cherubini

Journal of neurophysiology 109:1174-81 PubMed23197456

2012

Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Shin Kim,Eunchai Kang,Yuichi Makino,Sungjin Park,Jung Hoon Shin,Hongjun Song,Pierre Launay,David J Linden

PloS one 7:e45072 PubMed23028768

2012

Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A (Htr1a) receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Gilda Baccini,Boris Mlinar,Enrica Audero,Cornelius Thilo Gross,Renato Corradetti
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