MW 368.23 Da, Purity >98%. Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Soluble in 1 ml water to give specified mM/ml concentration.
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- eLife 10:2021Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChang-Rui Chen,Yu-Heng Zhong,Shan Jiang,Wei Xu,Lei Xiao,Zan Wang,Wei-Min Qu,Zhi-Li HuangPubMed 34787078
- Sleep 43:2019Lesion of intergeniculate leaflet GABAergic neurons attenuates sleep in mice exposed to light.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuan-Ying Shi,Wei Xu,Han Guo,Hui Dong,Wei-Min Qu,Zhi-Li HuangPubMed 31552427
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:5486-982013Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiulia Quattrocolo,Gianmaria MaccaferriPubMed 23536064
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:4768-812013Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPierre F Apostolides,Laurence O TrussellPubMed 23486948
- The Journal of physiology 591:2541-612013Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKristal Tucker et. al.PubMed 23478133
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:1828-322013Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPu-Yeh Wu,Yu-Yin Huang,Chien-Chun Chen,Tsan-Ting Hsu,Yen-Chu Lin,Ju-Yun Weng,Ta-Chun Chien,Irene H Cheng,Cheng-Chang LienPubMed 23365222
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:1790-62013Distinct modes of dopamine and GABA release in a dual transmitter neuron.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria Borisovska,AeSoon L Bensen,Gene Chong,Gary L WestbrookPubMed 23365218
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:1044-92013In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarilena Griguoli,Giada Cellot,Enrico CherubiniPubMed 23325242
- Journal of neurophysiology 109:1174-812012Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYu Shin Kim,Eunchai Kang,Yuichi Makino,Sungjin Park,Jung Hoon Shin,Hongjun Song,Pierre Launay,David J LindenPubMed 23197456
- PloS one 7:e450722012Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A (Htr1a) receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGilda Baccini et. al.PubMed 23028768
Key facts
- CAS number
- 104104-50-9
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 368.23 Da
- Molecular formula
- C15H18BrN3O3
- PubChem identifier
- 107895
- Nature
- Synthetic
Target data
Alternative names
AW061132, B230208N19Rik, CAE 2, ECA 2, ECA4, ECA5, EIEE19, EJM, EJM5, GAA 5, GABA, GABA A, GABA A Receptor alpha 3, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA alpha receptor beta-2 subunit, GABA subunit A receptor alpha 6, GABA(A) receptor, GABA(A) receptor beta 1, GABA(A) receptor beta 2, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-3, GABA(A) receptor subunit alpha-4, GABA(A) receptor subunit alpha-5, GABA(A) receptor subunit alpha-6, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit beta-3, GABA(A) receptor subunit delta, GABA(A) receptor subunit gamma-1, GABA(A) receptor subunit gamma-2, GABA(A) receptor subunit gamma-3, GABA(A) receptor subunit pi, GABA(A) receptor, alpha 1, GABA-A receptor, beta-1 polypeptide, GABA-A receptor, beta-2 polypeptide, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 3, GABR A3, GABR B3, GABR G3, GABRA 1, GABRA 5, GABRA 6, GABRB2, GABRG 1, GABRG 2, GABRP, GARB1, GBRA1_HUMAN, GBRA3_HUMAN, GBRA4_HUMAN, GBRA5_HUMAN, GBRA6_HUMAN, GBRB1_HUMAN, GBRB2_HUMAN, GBRB3_HUMAN, GBRD_HUMAN, GBRG1_HUMAN, GBRG2_HUMAN, GBRG3_HUMAN, GBRP_HUMAN, GC138184, GEFSP 3, Gaba receptor alpha 1 polypeptide, GabaA/BZ, Gamma Aminobutyric Acid A Receptor Beta 1, Gamma Aminobutyric Acid Receptor , beta-1, Gamma aminobutyric acid (GABA A) receptor subunit gamma 1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 3, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid (GABA) A receptor beta 1, Gamma aminobutyric acid (GABA) A receptor beta 3, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor gamma 3, Gamma aminobutyric acid (GABA) A receptor pi, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 3, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid A receptor, gamma 1, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid GABA A receptor delta, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-6, Gamma-aminobutyric acid receptor subunit beta-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Gamma-aminobutyric acid receptor subunit gamma-1, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit pi, Gamma-aminobutyric-acid receptor subunit beta-2, MGC116903, MGC116904, MGC126386, MGC126387, MGC33793, MGC45284, MGC9051
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MW 368.23 Da, Purity >98%. Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Soluble in 1 ml water to give specified mM/ml concentration.
Key facts
- CAS number
- 104104-50-9
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 368.23 Da
- Molecular formula
- C15H18BrN3O3
- PubChem identifier
- 107895
- Nature
- Synthetic
- Biochemical name
- 1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide
- Biological description
Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Soluble in 1 ml water to give specified mM/ml concentration.- Canonical SMILES
- COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br
- InChI
- InChI=1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H
- InChIKey
- GFZHNFOGCMEYTA-UHFFFAOYSA-N
- IUPAC name
- 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - SR95531 (Gabazine) (mM/ml), GABAA antagonist (ab144487)
2D chemical structure image of ab144487, SR95531 (Gabazine) (mM/ml), GABAA antagonist
Errington et al PLoS One. 2011; 6(4): e19021. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Functional Studies - SR95531 (Gabazine) (mM/ml), GABAA antagonist (ab144487)
Increased tonic GABA currents and altered IPSC properties in TC neurons of SSADH−/− mice.C, representative current traces from thalamocortical neurons of WT (left) and SSADH−/− (right) mice showing the difference in tonic current amplitude between the two genotypes. Dotted lines represent the initial baseline current prior to the focal application of 50 μM GBZ (white bar).
GBZ = Gabazine.
(From Figure 1 of Erringtom et al).
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